The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral blood
Aim. To assess the relationship between plasma chitotiosidase (CHIT) level and mortality in hospitalized patients with COVID-19. Materials and methods. 347 hospitalized patients with COVID-19 were enrolled in our single-center cohort prospective observational study. On the first day of hospitaliz...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2023-09-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/595925/135396 |
| _version_ | 1797634648558272512 |
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| author | Ekaterina S. Schelkanovtseva Georgy O. Isaev Olga Yu. Mironova Alexander A. Balakhonov Alexey V. Skvortsov Ilya O. Nagornov Aleksandr Yu. Suvorov Victor V. Fomin Alexandr S. Panferov |
| author_facet | Ekaterina S. Schelkanovtseva Georgy O. Isaev Olga Yu. Mironova Alexander A. Balakhonov Alexey V. Skvortsov Ilya O. Nagornov Aleksandr Yu. Suvorov Victor V. Fomin Alexandr S. Panferov |
| author_sort | Ekaterina S. Schelkanovtseva |
| collection | DOAJ |
| description | Aim. To assess the relationship between plasma chitotiosidase (CHIT) level and mortality in hospitalized patients with COVID-19.
Materials and methods. 347 hospitalized patients with COVID-19 were enrolled in our single-center cohort prospective observational study. On the first day of hospitalization the patients were assessed by the level of CHIT in the venosus blood to addition to default laboratory examinations. The primary endpoint was all-cause death. The survival after hospital discharge were assessed via phone calls on 90 and 180 days since inclusion to the study (NCT04752085).
Results. Our study included 347 patients. The first symptoms appeared in 7 days [5; 7] before hospitalization; 283 (84.3%) patients had less than 50% of the involvement of the lung tissue to the inflammation process (CT 02); 36 (10.4%) patients had died since the start of our investigation; 30 (83.3%) of them died during hospitalization, others -no later than 60 days; 68 (19%) people didnt answer during phone call. The survivor's activity of the enzyme in the deceased was significantly lower in compare to deceased patients (90.5 [40.2; 178.0] nmol/h/mL vs 180.0 [77.2; 393.2] nmol/h/mL; p=0.001). Survivor of the patients with a higher level of the activity of the CHIT (more than 171 nmol/h/mL) was statically significantly lower.
Conclusion. Rising of the CHIT's activity more than 171 nmol/h/mL might be an early independent predictor of the bad prognosis of the patients, who were hospitalized with COVID-19 infection. |
| first_indexed | 2024-03-11T12:10:36Z |
| format | Article |
| id | doaj.art-4bdd10b18d91416ca3d77428ced65f5a |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-03-11T12:10:36Z |
| publishDate | 2023-09-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-4bdd10b18d91416ca3d77428ced65f5a2023-11-07T14:01:32Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422023-09-0195754354710.26442/00403660.2023.07.20228078318The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral bloodEkaterina S. Schelkanovtseva0https://orcid.org/0000-0001-9098-4098Georgy O. Isaev1https://orcid.org/0000-0002-4871-8797Olga Yu. Mironova2https://orcid.org/0000-0002-5820-1759Alexander A. Balakhonov3https://orcid.org/0000-0002-1166-9856Alexey V. Skvortsov4https://orcid.org/0000-0001-8743-5207Ilya O. Nagornov5https://orcid.org/0000-0001-9368-1594Aleksandr Yu. Suvorov6https://orcid.org/0000-0002-2224-0019Victor V. Fomin7https://orcid.org/0000-0002-2682-4417Alexandr S. Panferov8https://orcid.org/0000-0002-4324-7615Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Lomonosov Moscow State UniversityBochkov Medical Genetic Research CenterSechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Aim. To assess the relationship between plasma chitotiosidase (CHIT) level and mortality in hospitalized patients with COVID-19. Materials and methods. 347 hospitalized patients with COVID-19 were enrolled in our single-center cohort prospective observational study. On the first day of hospitalization the patients were assessed by the level of CHIT in the venosus blood to addition to default laboratory examinations. The primary endpoint was all-cause death. The survival after hospital discharge were assessed via phone calls on 90 and 180 days since inclusion to the study (NCT04752085). Results. Our study included 347 patients. The first symptoms appeared in 7 days [5; 7] before hospitalization; 283 (84.3%) patients had less than 50% of the involvement of the lung tissue to the inflammation process (CT 02); 36 (10.4%) patients had died since the start of our investigation; 30 (83.3%) of them died during hospitalization, others -no later than 60 days; 68 (19%) people didnt answer during phone call. The survivor's activity of the enzyme in the deceased was significantly lower in compare to deceased patients (90.5 [40.2; 178.0] nmol/h/mL vs 180.0 [77.2; 393.2] nmol/h/mL; p=0.001). Survivor of the patients with a higher level of the activity of the CHIT (more than 171 nmol/h/mL) was statically significantly lower. Conclusion. Rising of the CHIT's activity more than 171 nmol/h/mL might be an early independent predictor of the bad prognosis of the patients, who were hospitalized with COVID-19 infection.https://ter-arkhiv.ru/0040-3660/article/viewFile/595925/135396chitotriosidasecoronaviruscovid-19biomarkersmortalityprognosis |
| spellingShingle | Ekaterina S. Schelkanovtseva Georgy O. Isaev Olga Yu. Mironova Alexander A. Balakhonov Alexey V. Skvortsov Ilya O. Nagornov Aleksandr Yu. Suvorov Victor V. Fomin Alexandr S. Panferov The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral blood Терапевтический архив chitotriosidase coronavirus covid-19 biomarkers mortality prognosis |
| title | The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral blood |
| title_full | The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral blood |
| title_fullStr | The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral blood |
| title_full_unstemmed | The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral blood |
| title_short | The survival prediction of hospitalized patients with COVID-19: the role of chitotriosidase level in peripheral blood |
| title_sort | survival prediction of hospitalized patients with covid 19 the role of chitotriosidase level in peripheral blood |
| topic | chitotriosidase coronavirus covid-19 biomarkers mortality prognosis |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/595925/135396 |
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