Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development
Breast cancer (BC) is one of the most common malignant tumors in women globally, and its occurrence has surpassed lung cancer and become the biggest threat for women. At present, breast cancer treatment includes surgical resection or postoperative chemotherapy and radiotherapy. However, tumor relaps...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222200004X |
| _version_ | 1798034436291297280 |
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| author | Tianshu Zhang Huimin Zhou Kexin Wang Xiaowei Wang Mengyan Wang Wenxia Zhao Xiaoming Xi Yang Li Meilian Cai Wuli Zhao Yanni Xu Rongguang Shao |
| author_facet | Tianshu Zhang Huimin Zhou Kexin Wang Xiaowei Wang Mengyan Wang Wenxia Zhao Xiaoming Xi Yang Li Meilian Cai Wuli Zhao Yanni Xu Rongguang Shao |
| author_sort | Tianshu Zhang |
| collection | DOAJ |
| description | Breast cancer (BC) is one of the most common malignant tumors in women globally, and its occurrence has surpassed lung cancer and become the biggest threat for women. At present, breast cancer treatment includes surgical resection or postoperative chemotherapy and radiotherapy. However, tumor relapse and metastasis usually lead to current therapy failure thanks to breast cancer stem cells (BCSCs)-mediated tumorigenicity and drug resistance. Drug resistance is mainly due to the long-term quiescent G0 phase, strong DNA repairability, and high expression of ABC transporter, and the tumorigenicity is reflected in the activation of various proliferation pathways related to BCSCs. Therefore, understanding the characteristics of BCSCs and their intracellular and extracellular molecular mechanisms is crucial for the development of targeted drugs for BCSCs. To this end, we discussed the latest developments in BCSCs research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs，such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling, immunomicroenviroment and summarizes targeting therapy strategies for stemness maintenance and differentiation, which provides a theoretical basis for further exploration of treating breast cancer and preventing relapse derived from BCSCs. |
| first_indexed | 2024-04-11T20:44:21Z |
| format | Article |
| id | doaj.art-4bdd174840d84e998e3a6627c910f495 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T20:44:21Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-4bdd174840d84e998e3a6627c910f4952022-12-22T04:04:06ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-03-01147112616Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer developmentTianshu Zhang0Huimin Zhou1Kexin Wang2Xiaowei Wang3Mengyan Wang4Wenxia Zhao5Xiaoming Xi6Yang Li7Meilian Cai8Wuli Zhao9Yanni Xu10Rongguang Shao11Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaCorresponding authors.; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaCorresponding authors.; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaBreast cancer (BC) is one of the most common malignant tumors in women globally, and its occurrence has surpassed lung cancer and become the biggest threat for women. At present, breast cancer treatment includes surgical resection or postoperative chemotherapy and radiotherapy. However, tumor relapse and metastasis usually lead to current therapy failure thanks to breast cancer stem cells (BCSCs)-mediated tumorigenicity and drug resistance. Drug resistance is mainly due to the long-term quiescent G0 phase, strong DNA repairability, and high expression of ABC transporter, and the tumorigenicity is reflected in the activation of various proliferation pathways related to BCSCs. Therefore, understanding the characteristics of BCSCs and their intracellular and extracellular molecular mechanisms is crucial for the development of targeted drugs for BCSCs. To this end, we discussed the latest developments in BCSCs research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs，such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling, immunomicroenviroment and summarizes targeting therapy strategies for stemness maintenance and differentiation, which provides a theoretical basis for further exploration of treating breast cancer and preventing relapse derived from BCSCs.http://www.sciencedirect.com/science/article/pii/S075333222200004XBreast cancerCancer stem cellsMolecular mechanismMarker of BCSCsNOTCH |
| spellingShingle | Tianshu Zhang Huimin Zhou Kexin Wang Xiaowei Wang Mengyan Wang Wenxia Zhao Xiaoming Xi Yang Li Meilian Cai Wuli Zhao Yanni Xu Rongguang Shao Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development Biomedicine & Pharmacotherapy Breast cancer Cancer stem cells Molecular mechanism Marker of BCSCs NOTCH |
| title | Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development |
| title_full | Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development |
| title_fullStr | Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development |
| title_full_unstemmed | Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development |
| title_short | Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development |
| title_sort | role molecular mechanism and the potential target of breast cancer stem cells in breast cancer development |
| topic | Breast cancer Cancer stem cells Molecular mechanism Marker of BCSCs NOTCH |
| url | http://www.sciencedirect.com/science/article/pii/S075333222200004X |
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