The Antiviral Agent Cidofovir Induces DNA Damage and Mitotic Catastrophe in HPV-Positive and -Negative Head and Neck Squamous Cell Carcinomas In Vitro

The Antiviral Agent Cidofovir Induces DNA Damage and Mitotic Catastrophe in HPV-Positive and -Negative Head and Neck Squamous Cell Carcinomas In Vitro

Cidofovir (CDV) is an antiviral agent with antiproliferative properties. The aim of our study was to investigate the efficacy of CDV in HPV-positive and -negative head and neck squamous cell carcinoma (HNSCC) cell lines and whether it is caused by a difference in response to DNA damage. Upon CDV tre...

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Bibliographic Details
Main Authors: Femke Verhees, Dion Legemaate, Imke Demers, Robin Jacobs, Wisse Evert Haakma, Mat Rousch, Bernd Kremer, Ernst Jan Speel
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
human papillomavirus
head and neck cancer
double-stranded DNA breaks
DNA repair
cell line
cyclin B1
Aurora Kinase A
Online Access:https://www.mdpi.com/2072-6694/11/7/919

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