Navigating ethical challenges of conducting randomized clinical trials on COVID-19
Abstract Background The contemporary frameworks for clinical research require informed consent for research participation that includes disclosure of material information, comprehension of disclosed information and voluntary consent to research participation. There is thus an urgent need to test, an...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-01-01
|
| Series: | Philosophy, Ethics, and Humanities in Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13010-022-00115-3 |
| _version_ | 1819280392485601280 |
|---|---|
| author | Dan Kabonge Kaye |
| author_facet | Dan Kabonge Kaye |
| author_sort | Dan Kabonge Kaye |
| collection | DOAJ |
| description | Abstract Background The contemporary frameworks for clinical research require informed consent for research participation that includes disclosure of material information, comprehension of disclosed information and voluntary consent to research participation. There is thus an urgent need to test, and an ethical imperative, to test, modify or refine medications or healthcare plans that could reduce patient morbidity, lower healthcare costs or strengthen healthcare systems. Methods Conceptual review. Discussion Although some allocation principles seem better than others, no single moral principle allocates interventions justly, necessitating combining the moral principles into multiprinciple allocation systems. The urgency notwithstanding, navigating ethical challenges related to conducting corona virus disease (COVID-19) clinical trials is mandatory, in order to safeguard the safety and welfare of research participants, ensure autonomy of participants, reduce possibilities for exploitation and ensure opportunities for research participation. The ethical challenges to can be categorized as challenges in allocation of resources for research; challenges of clinical equipoise in relation to the research questions; challenges of understanding disclosed information in potential participants; and challenges in obtaining informed consent. Conclusion To navigate these challenges, stakeholders need a delicate balance of moral principles during allocation of resources for research. Investigators need to apply information processing theories to aid decision-making about research participation or employ acceptable modifications to improve the informed consent process. Research and ethics committees should strengthen research review and oversight to ensure rigor, responsiveness and transparency. |
| first_indexed | 2024-12-24T00:43:04Z |
| format | Article |
| id | doaj.art-4be073f362e24be8862887b16079ea82 |
| institution | Directory Open Access Journal |
| issn | 1747-5341 |
| language | English |
| last_indexed | 2024-12-24T00:43:04Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Philosophy, Ethics, and Humanities in Medicine |
| spelling | doaj.art-4be073f362e24be8862887b16079ea822022-12-21T17:23:53ZengBMCPhilosophy, Ethics, and Humanities in Medicine1747-53412022-01-0117111110.1186/s13010-022-00115-3Navigating ethical challenges of conducting randomized clinical trials on COVID-19Dan Kabonge Kaye0College of Health Sciences, Department of Obstetrics and Gynecology, Makerere UniversityAbstract Background The contemporary frameworks for clinical research require informed consent for research participation that includes disclosure of material information, comprehension of disclosed information and voluntary consent to research participation. There is thus an urgent need to test, and an ethical imperative, to test, modify or refine medications or healthcare plans that could reduce patient morbidity, lower healthcare costs or strengthen healthcare systems. Methods Conceptual review. Discussion Although some allocation principles seem better than others, no single moral principle allocates interventions justly, necessitating combining the moral principles into multiprinciple allocation systems. The urgency notwithstanding, navigating ethical challenges related to conducting corona virus disease (COVID-19) clinical trials is mandatory, in order to safeguard the safety and welfare of research participants, ensure autonomy of participants, reduce possibilities for exploitation and ensure opportunities for research participation. The ethical challenges to can be categorized as challenges in allocation of resources for research; challenges of clinical equipoise in relation to the research questions; challenges of understanding disclosed information in potential participants; and challenges in obtaining informed consent. Conclusion To navigate these challenges, stakeholders need a delicate balance of moral principles during allocation of resources for research. Investigators need to apply information processing theories to aid decision-making about research participation or employ acceptable modifications to improve the informed consent process. Research and ethics committees should strengthen research review and oversight to ensure rigor, responsiveness and transparency.https://doi.org/10.1186/s13010-022-00115-3COVID-19Resource allocationClinical trials in emergency careEthical ChallengesInformed consentNavigating Ethical Challenges |
| spellingShingle | Dan Kabonge Kaye Navigating ethical challenges of conducting randomized clinical trials on COVID-19 Philosophy, Ethics, and Humanities in Medicine COVID-19 Resource allocation Clinical trials in emergency care Ethical Challenges Informed consent Navigating Ethical Challenges |
| title | Navigating ethical challenges of conducting randomized clinical trials on COVID-19 |
| title_full | Navigating ethical challenges of conducting randomized clinical trials on COVID-19 |
| title_fullStr | Navigating ethical challenges of conducting randomized clinical trials on COVID-19 |
| title_full_unstemmed | Navigating ethical challenges of conducting randomized clinical trials on COVID-19 |
| title_short | Navigating ethical challenges of conducting randomized clinical trials on COVID-19 |
| title_sort | navigating ethical challenges of conducting randomized clinical trials on covid 19 |
| topic | COVID-19 Resource allocation Clinical trials in emergency care Ethical Challenges Informed consent Navigating Ethical Challenges |
| url | https://doi.org/10.1186/s13010-022-00115-3 |
| work_keys_str_mv | AT dankabongekaye navigatingethicalchallengesofconductingrandomizedclinicaltrialsoncovid19 |