The false alarm: Rosai–Dorfman disease of breast: case report
Abstract Introduction Rosai–Dorfman disease is a rare disorder caused by benign proliferation of histiocytes and thus also called sinus histiocytosis with massive lymphadenopathy. It is typically known to involve lymph nodes but can also affect extra nodal sites with breast involvement being extreme...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-04-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-022-00731-1 |
| _version_ | 1828734063825911808 |
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| author | Sanjivanee Ingole V. Pavithra Sandhya Sundaram Leena Dennis Joseph Syed Altaf Hussain Bhawna Dev |
| author_facet | Sanjivanee Ingole V. Pavithra Sandhya Sundaram Leena Dennis Joseph Syed Altaf Hussain Bhawna Dev |
| author_sort | Sanjivanee Ingole |
| collection | DOAJ |
| description | Abstract Introduction Rosai–Dorfman disease is a rare disorder caused by benign proliferation of histiocytes and thus also called sinus histiocytosis with massive lymphadenopathy. It is typically known to involve lymph nodes but can also affect extra nodal sites with breast involvement being extremely rare. This disease is known to mimic malignancy clinically and on imaging. The final verdict is through histopathological evaluation. Case presentation We present a case of a 21-year-old female who presented with a palpable suspicious lump in right breast. Ultrasound, mammogram and MRI breast were done followed by fine needle aspiration, which showed lymphocytes and occasional histiocytes, which is suggestive of a lymphoid process. Surgical excision was done due to high suspicion of low-grade angiosarcoma in spite of a negative cytology. Diagnosis of Rosai–Dorfman disease was concluded after histopathological evaluation and was further confirmed by immunohistochemical staining by immunohistochemical markers S-100 and CD68. Conclusion Rosai–Dorfman disease can present as low-grade angiosarcoma clinically as well as on imaging. There is a need for high level of suspicion to rule out benign mimics of malignancy to avoid radical surgery. Final diagnosis is by histopathology along with immunohistochemical staining. |
| first_indexed | 2024-04-12T22:41:18Z |
| format | Article |
| id | doaj.art-4be07e596daf465cab64e36a141675db |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-04-12T22:41:18Z |
| publishDate | 2022-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-4be07e596daf465cab64e36a141675db2022-12-22T03:13:43ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622022-04-015311610.1186/s43055-022-00731-1The false alarm: Rosai–Dorfman disease of breast: case reportSanjivanee Ingole0V. Pavithra1Sandhya Sundaram2Leena Dennis Joseph3Syed Altaf Hussain4Bhawna Dev5Sri Ramachandra Institute of Higher Education and Research (Deemed To Be University)Sri Ramachandra Institute of Higher Education and Research (Deemed To Be University)Sri Ramachandra Institute of Higher Education and Research (Deemed To Be University)Sri Ramachandra Institute of Higher Education and Research (Deemed To Be University)Sri Ramachandra Institute of Higher Education and Research (Deemed To Be University)Sri Ramachandra Institute of Higher Education and Research (Deemed To Be University)Abstract Introduction Rosai–Dorfman disease is a rare disorder caused by benign proliferation of histiocytes and thus also called sinus histiocytosis with massive lymphadenopathy. It is typically known to involve lymph nodes but can also affect extra nodal sites with breast involvement being extremely rare. This disease is known to mimic malignancy clinically and on imaging. The final verdict is through histopathological evaluation. Case presentation We present a case of a 21-year-old female who presented with a palpable suspicious lump in right breast. Ultrasound, mammogram and MRI breast were done followed by fine needle aspiration, which showed lymphocytes and occasional histiocytes, which is suggestive of a lymphoid process. Surgical excision was done due to high suspicion of low-grade angiosarcoma in spite of a negative cytology. Diagnosis of Rosai–Dorfman disease was concluded after histopathological evaluation and was further confirmed by immunohistochemical staining by immunohistochemical markers S-100 and CD68. Conclusion Rosai–Dorfman disease can present as low-grade angiosarcoma clinically as well as on imaging. There is a need for high level of suspicion to rule out benign mimics of malignancy to avoid radical surgery. Final diagnosis is by histopathology along with immunohistochemical staining.https://doi.org/10.1186/s43055-022-00731-1Rosai–Dorfman diseaseSinus histiocytosisBreastBenign mimic of malignancy |
| spellingShingle | Sanjivanee Ingole V. Pavithra Sandhya Sundaram Leena Dennis Joseph Syed Altaf Hussain Bhawna Dev The false alarm: Rosai–Dorfman disease of breast: case report The Egyptian Journal of Radiology and Nuclear Medicine Rosai–Dorfman disease Sinus histiocytosis Breast Benign mimic of malignancy |
| title | The false alarm: Rosai–Dorfman disease of breast: case report |
| title_full | The false alarm: Rosai–Dorfman disease of breast: case report |
| title_fullStr | The false alarm: Rosai–Dorfman disease of breast: case report |
| title_full_unstemmed | The false alarm: Rosai–Dorfman disease of breast: case report |
| title_short | The false alarm: Rosai–Dorfman disease of breast: case report |
| title_sort | false alarm rosai dorfman disease of breast case report |
| topic | Rosai–Dorfman disease Sinus histiocytosis Breast Benign mimic of malignancy |
| url | https://doi.org/10.1186/s43055-022-00731-1 |
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