RANKL biology: bone metabolism, the immune system, and beyond
Abstract Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signaling receptor RANK, or decoy receptor osteoprotegerin (OPG) lead to bone diseases suc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
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| Series: | Inflammation and Regeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41232-019-0111-3 |
| _version_ | 1818459680335200256 |
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| author | Takehito Ono Mikihito Hayashi Fumiyuki Sasaki Tomoki Nakashima |
| author_facet | Takehito Ono Mikihito Hayashi Fumiyuki Sasaki Tomoki Nakashima |
| author_sort | Takehito Ono |
| collection | DOAJ |
| description | Abstract Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signaling receptor RANK, or decoy receptor osteoprotegerin (OPG) lead to bone diseases such as osteopetrosis, the RANKL/RANK/OPG system is essential for bone resorption. RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The essentiality of RANKL in the bone and the immune systems lies at the root of the field of “osteoimmunology.” Furthermore, this cytokine functions beyond the domains of bone metabolism and the immune system, e.g., mammary gland and hair follicle formation, body temperature regulation, muscle metabolism, and tumor development. In this review, we will summarize the current understanding of the functions of the RANKL/RANK/OPG system in biological processes. |
| first_indexed | 2024-12-14T23:18:12Z |
| format | Article |
| id | doaj.art-4be31d9ac3f5417295c429639533be8e |
| institution | Directory Open Access Journal |
| issn | 1880-8190 |
| language | English |
| last_indexed | 2024-12-14T23:18:12Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Inflammation and Regeneration |
| spelling | doaj.art-4be31d9ac3f5417295c429639533be8e2022-12-21T22:44:01ZengBMCInflammation and Regeneration1880-81902020-02-0140111610.1186/s41232-019-0111-3RANKL biology: bone metabolism, the immune system, and beyondTakehito Ono0Mikihito Hayashi1Fumiyuki Sasaki2Tomoki Nakashima3Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental UniversityDepartment of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental UniversityDepartment of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental UniversityDepartment of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental UniversityAbstract Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signaling receptor RANK, or decoy receptor osteoprotegerin (OPG) lead to bone diseases such as osteopetrosis, the RANKL/RANK/OPG system is essential for bone resorption. RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The essentiality of RANKL in the bone and the immune systems lies at the root of the field of “osteoimmunology.” Furthermore, this cytokine functions beyond the domains of bone metabolism and the immune system, e.g., mammary gland and hair follicle formation, body temperature regulation, muscle metabolism, and tumor development. In this review, we will summarize the current understanding of the functions of the RANKL/RANK/OPG system in biological processes.https://doi.org/10.1186/s41232-019-0111-3RANKLRANKOPGBoneImmune systemOsteoimmunology |
| spellingShingle | Takehito Ono Mikihito Hayashi Fumiyuki Sasaki Tomoki Nakashima RANKL biology: bone metabolism, the immune system, and beyond Inflammation and Regeneration RANKL RANK OPG Bone Immune system Osteoimmunology |
| title | RANKL biology: bone metabolism, the immune system, and beyond |
| title_full | RANKL biology: bone metabolism, the immune system, and beyond |
| title_fullStr | RANKL biology: bone metabolism, the immune system, and beyond |
| title_full_unstemmed | RANKL biology: bone metabolism, the immune system, and beyond |
| title_short | RANKL biology: bone metabolism, the immune system, and beyond |
| title_sort | rankl biology bone metabolism the immune system and beyond |
| topic | RANKL RANK OPG Bone Immune system Osteoimmunology |
| url | https://doi.org/10.1186/s41232-019-0111-3 |
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