Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study
Abstract Background Previous studies have shown that the monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a predictor of various diseases such as coronary heart disease, diabetic microangiopathy, and metabolic syndrome. However, there are few scientific reports on the correlat...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-00966-z |
| _version_ | 1818988156432678912 |
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| author | Yuexi Li Xiaoqin Liu Yuhan Luo |
| author_facet | Yuexi Li Xiaoqin Liu Yuhan Luo |
| author_sort | Yuexi Li |
| collection | DOAJ |
| description | Abstract Background Previous studies have shown that the monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a predictor of various diseases such as coronary heart disease, diabetic microangiopathy, and metabolic syndrome. However, there are few scientific reports on the correlation between MHR and serum uric acid. The objective of this report is to explore the relationship between MHR and serum uric acid in Chinese adults. Methods This cross-sectional study included 646 participants from southwest China who underwent a health examination at the Health Management Center of Deyang People’s Hospital. The examination included blood pressure readings, routine blood tests (lipid, fasting glucose, serum transaminase, and serum uric acid levels), and various standardized questionnaires. We employed a generalized additive model and smoothed curve fitting to explore the relationship between MHR and serum uric acid levels. We then performed subgroup analyses to investigate the robustness of this relationship. Results After adjusting for confounders (age, sex, body mass index, systolic blood pressure, diastolic blood pressure, aspartate transaminase, alanine aminotransferase, fasting glucose, total cholesterol, low-density lipoprotein, smoking, drinking, and exercise status), MHR was found to be positively correlated with serum uric acid levels (P < 0.001). The smoothing curve showed an approximately linear correlation between MHR and serum uric acid levels, and the linear correlation coefficient was 146.74 (95% CI 96.16–197.33, P < 0.0001). The subgroup analyses showed that the effect of MHR on serum uric acid levels was smaller in occasional smokers and smokers than in nonsmokers (P = 0.0194). Conclusion MHR was significantly and positively correlated with serum uric acid levels. Additionally, the effect of MHR on serum uric acid levels was lower in the individuals who smoked more. |
| first_indexed | 2024-12-20T19:18:06Z |
| format | Article |
| id | doaj.art-4be3f2c11bdc4be2a93057d23e45cdba |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-20T19:18:06Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-4be3f2c11bdc4be2a93057d23e45cdba2022-12-21T19:29:04ZengBMCBMC Endocrine Disorders1472-68232022-02-012211910.1186/s12902-022-00966-zMonocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional studyYuexi Li0Xiaoqin Liu1Yuhan Luo2Health Management Center, Deyang People’s HospitalHealth Management Center, Deyang People’s HospitalHealth Management Center, Deyang People’s HospitalAbstract Background Previous studies have shown that the monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a predictor of various diseases such as coronary heart disease, diabetic microangiopathy, and metabolic syndrome. However, there are few scientific reports on the correlation between MHR and serum uric acid. The objective of this report is to explore the relationship between MHR and serum uric acid in Chinese adults. Methods This cross-sectional study included 646 participants from southwest China who underwent a health examination at the Health Management Center of Deyang People’s Hospital. The examination included blood pressure readings, routine blood tests (lipid, fasting glucose, serum transaminase, and serum uric acid levels), and various standardized questionnaires. We employed a generalized additive model and smoothed curve fitting to explore the relationship between MHR and serum uric acid levels. We then performed subgroup analyses to investigate the robustness of this relationship. Results After adjusting for confounders (age, sex, body mass index, systolic blood pressure, diastolic blood pressure, aspartate transaminase, alanine aminotransferase, fasting glucose, total cholesterol, low-density lipoprotein, smoking, drinking, and exercise status), MHR was found to be positively correlated with serum uric acid levels (P < 0.001). The smoothing curve showed an approximately linear correlation between MHR and serum uric acid levels, and the linear correlation coefficient was 146.74 (95% CI 96.16–197.33, P < 0.0001). The subgroup analyses showed that the effect of MHR on serum uric acid levels was smaller in occasional smokers and smokers than in nonsmokers (P = 0.0194). Conclusion MHR was significantly and positively correlated with serum uric acid levels. Additionally, the effect of MHR on serum uric acid levels was lower in the individuals who smoked more.https://doi.org/10.1186/s12902-022-00966-zMonocytesHigh-density lipoprotein cholesterolMonocyte to high-density lipoprotein cholesterol ratioSerum uric acid |
| spellingShingle | Yuexi Li Xiaoqin Liu Yuhan Luo Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study BMC Endocrine Disorders Monocytes High-density lipoprotein cholesterol Monocyte to high-density lipoprotein cholesterol ratio Serum uric acid |
| title | Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study |
| title_full | Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study |
| title_fullStr | Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study |
| title_full_unstemmed | Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study |
| title_short | Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study |
| title_sort | monocyte to high density lipoprotein cholesterol ratio and serum uric acid in chinese adults a cross sectional study |
| topic | Monocytes High-density lipoprotein cholesterol Monocyte to high-density lipoprotein cholesterol ratio Serum uric acid |
| url | https://doi.org/10.1186/s12902-022-00966-z |
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