The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - review
Introduction: Post-traumatic stress disorder (PTSD) is a common health issue of complex etiology significantly deteriorating functioning in everyday life. It may develop as a result of exposure to traumatic events like traffic accidents, war experience, sexual abuse and domestic violence. Current m...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2023-08-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/45017 |
| _version_ | 1827865616744185856 |
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| author | Karol Womperski Rafał Bogacz Magdalena Gaik Inga Magda Justyna Woźniak Ewa Uram Magdalena Osuch |
| author_facet | Karol Womperski Rafał Bogacz Magdalena Gaik Inga Magda Justyna Woźniak Ewa Uram Magdalena Osuch |
| author_sort | Karol Womperski |
| collection | DOAJ |
| description |
Introduction: Post-traumatic stress disorder (PTSD) is a common health issue of complex etiology significantly deteriorating functioning in everyday life. It may develop as a result of exposure to traumatic events like traffic accidents, war experience, sexual abuse and domestic violence. Current methods of treatment consist of trauma-oriented psychotherapy supported by selective serotonin reuptake inhibitors (SSRIs). Their efficacy is far from satisfactory thus a search for alternative methods is necessary. 3,4-Methylenedioxymethamphetamine (MDMA) commonly known as “ecstasy” seems to have promising results in the treatment of PTSD.
Aim of study: Review of current knowledge about MDMA-assisted therapy in PTSD, its possible mechanisms of action, efficacy and safety.
Methods and materials: A review of chosen literature from in PubMed database, GoogleScholar database in the years 2000-2023 was conducted using the following keywords:
“PTSD epidemiology”, “PTSD pathophysiology”, “PTSD neural activity”, “PTSD brain activity”, “MDMA PTSD”, “MDMA brain activity”, “MDMA neural activity”, “MDMA neurotoxicity”, “MDMA PTSD therapy”, “MDMA safety”, “MDMA caffeine”
Results: MDMA-assisted therapy has promising effects in PTSD treatment and its safety profile is satisfactory. The improvement in symptoms occurs most likely due to its modulating activity on brain structures responsible for threat detection and emotion processing.
Conclusions: Further research is necessary to assess MDMA-assisted therapy in PTSD, especially direct comparison of its efficacy versus first-line treatment SSRIs and assessment of its long-term-safety.
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| first_indexed | 2024-03-12T14:51:35Z |
| format | Article |
| id | doaj.art-4be46d50b0de49fd9aec5a68c917e669 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-03-12T14:51:35Z |
| publishDate | 2023-08-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-4be46d50b0de49fd9aec5a68c917e6692023-08-15T10:48:22ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062023-08-0143110.12775/JEHS.2023.43.01.007The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - reviewKarol Womperski0Rafał Bogacz1Magdalena Gaik2Inga Magda3Justyna Woźniak4Ewa Uram5Magdalena Osuch6Wrocław Medical University, Wybrzeże L. Pasteura 1, 50-367 WrocławLower Silesian Oncology Center in Wrocław, Plac Ludwika Hirszfelda 12, 53-413 WrocławLower Silesian Oncology Center in Wrocław, Plac Ludwika Hirszfelda 12, 53-413 Wrocław5 Military Clinical Hospital SPZOZ, Wrocławska 1-3, 30-901 KrakówWrocław Medical University, Wybrzeże L. Pasteura 1, 50-367 WrocławLower Silesian Oncology Center in Wrocław, Plac Ludwika Hirszfelda 12, 53-413 WrocławJ. Dietl Specialist Hospital, Skarbowa 4, 31-121 Kraków Introduction: Post-traumatic stress disorder (PTSD) is a common health issue of complex etiology significantly deteriorating functioning in everyday life. It may develop as a result of exposure to traumatic events like traffic accidents, war experience, sexual abuse and domestic violence. Current methods of treatment consist of trauma-oriented psychotherapy supported by selective serotonin reuptake inhibitors (SSRIs). Their efficacy is far from satisfactory thus a search for alternative methods is necessary. 3,4-Methylenedioxymethamphetamine (MDMA) commonly known as “ecstasy” seems to have promising results in the treatment of PTSD. Aim of study: Review of current knowledge about MDMA-assisted therapy in PTSD, its possible mechanisms of action, efficacy and safety. Methods and materials: A review of chosen literature from in PubMed database, GoogleScholar database in the years 2000-2023 was conducted using the following keywords: “PTSD epidemiology”, “PTSD pathophysiology”, “PTSD neural activity”, “PTSD brain activity”, “MDMA PTSD”, “MDMA brain activity”, “MDMA neural activity”, “MDMA neurotoxicity”, “MDMA PTSD therapy”, “MDMA safety”, “MDMA caffeine” Results: MDMA-assisted therapy has promising effects in PTSD treatment and its safety profile is satisfactory. The improvement in symptoms occurs most likely due to its modulating activity on brain structures responsible for threat detection and emotion processing. Conclusions: Further research is necessary to assess MDMA-assisted therapy in PTSD, especially direct comparison of its efficacy versus first-line treatment SSRIs and assessment of its long-term-safety. https://apcz.umk.pl/JEHS/article/view/45017PTSDMDMAPTSD treatmentMDMA treatmentPTSD MDMAMDMA in medicine |
| spellingShingle | Karol Womperski Rafał Bogacz Magdalena Gaik Inga Magda Justyna Woźniak Ewa Uram Magdalena Osuch The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - review Journal of Education, Health and Sport PTSD MDMA PTSD treatment MDMA treatment PTSD MDMA MDMA in medicine |
| title | The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - review |
| title_full | The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - review |
| title_fullStr | The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - review |
| title_full_unstemmed | The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - review |
| title_short | The use of 3,4-Methylenedioxymethamphetamine (MDMA) in the treatment of Post-Traumatic Stress Disorder (PTSD) - review |
| title_sort | use of 3 4 methylenedioxymethamphetamine mdma in the treatment of post traumatic stress disorder ptsd review |
| topic | PTSD MDMA PTSD treatment MDMA treatment PTSD MDMA MDMA in medicine |
| url | https://apcz.umk.pl/JEHS/article/view/45017 |
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