Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa
Abstract Background This study investigated the burden and predictors of canine E. coli urinary tract infections (UTI) and antimicrobial resistance among dogs presented at a veterinary teaching hospital in South Africa, 2007–2012. Methods The Cochran-Armitage trend test was used to investigate tempo...
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BMC
2018-07-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-018-1552-7 |
| _version_ | 1818034022860718080 |
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| author | Daniel Nenene Qekwana Lufuno Phophi Vinny Naidoo James Wabwire Oguttu Agricola Odoi |
| author_facet | Daniel Nenene Qekwana Lufuno Phophi Vinny Naidoo James Wabwire Oguttu Agricola Odoi |
| author_sort | Daniel Nenene Qekwana |
| collection | DOAJ |
| description | Abstract Background This study investigated the burden and predictors of canine E. coli urinary tract infections (UTI) and antimicrobial resistance among dogs presented at a veterinary teaching hospital in South Africa, 2007–2012. Methods The Cochran-Armitage trend test was used to investigate temporal trends while logistic regression models were used to investigate predictors (age, sex, breed, year) of E. coli infections and antimicrobial resistance (AMR). Results A total of 22.3% (168/755) of the urinary specimens tested positive for E. coli. A significant (p = 0.0004) decreasing temporal trend in the percentage of E. coli positive isolates was observed over the study period. There were high levels of AMR to penicillin-G (99%), clindamycin (100%), tylosine (95%), cephalothin (84%) but relatively low levels of resistance to enrofloxacin (16%), orbifloxacin (21%). Almost all (98%, 164/167) the isolates exhibited multidrug resistance (MDR), while only 11% (19/167) and 2% (4/167) exhibited extensive drug resistance (XDR) and pan-drug resistance (PDR), respectively. Conclusions Although, the risk of E. coli UTI declined during the study period, the risk of AMR increased. The high levels of AMR and MDR as well as the presence of XDR and PDR is concerning as these have the potential of affecting prognosis of UTI treatments. |
| first_indexed | 2024-12-10T06:32:33Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-10T06:32:33Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-4be47db72b484eb7ad426c1c790190532022-12-22T01:59:01ZengBMCBMC Veterinary Research1746-61482018-07-011411610.1186/s12917-018-1552-7Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South AfricaDaniel Nenene Qekwana0Lufuno Phophi1Vinny Naidoo2James Wabwire Oguttu3Agricola Odoi4Section Veterinary Public Health, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of PretoriaSection Veterinary Public Health, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of PretoriaBiomedical Research Centre (UPBRC), Faculty of Veterinary Science, University of PretoriaDepartment of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South AfricaSection Veterinary Public Health, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of PretoriaAbstract Background This study investigated the burden and predictors of canine E. coli urinary tract infections (UTI) and antimicrobial resistance among dogs presented at a veterinary teaching hospital in South Africa, 2007–2012. Methods The Cochran-Armitage trend test was used to investigate temporal trends while logistic regression models were used to investigate predictors (age, sex, breed, year) of E. coli infections and antimicrobial resistance (AMR). Results A total of 22.3% (168/755) of the urinary specimens tested positive for E. coli. A significant (p = 0.0004) decreasing temporal trend in the percentage of E. coli positive isolates was observed over the study period. There were high levels of AMR to penicillin-G (99%), clindamycin (100%), tylosine (95%), cephalothin (84%) but relatively low levels of resistance to enrofloxacin (16%), orbifloxacin (21%). Almost all (98%, 164/167) the isolates exhibited multidrug resistance (MDR), while only 11% (19/167) and 2% (4/167) exhibited extensive drug resistance (XDR) and pan-drug resistance (PDR), respectively. Conclusions Although, the risk of E. coli UTI declined during the study period, the risk of AMR increased. The high levels of AMR and MDR as well as the presence of XDR and PDR is concerning as these have the potential of affecting prognosis of UTI treatments.http://link.springer.com/article/10.1186/s12917-018-1552-7Antimicrobial resistanceE.coliUrinary tract infectionsDogCanineMultidrug resistance |
| spellingShingle | Daniel Nenene Qekwana Lufuno Phophi Vinny Naidoo James Wabwire Oguttu Agricola Odoi Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa BMC Veterinary Research Antimicrobial resistance E.coli Urinary tract infections Dog Canine Multidrug resistance |
| title | Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa |
| title_full | Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa |
| title_fullStr | Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa |
| title_full_unstemmed | Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa |
| title_short | Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa |
| title_sort | antimicrobial resistance among escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in south africa |
| topic | Antimicrobial resistance E.coli Urinary tract infections Dog Canine Multidrug resistance |
| url | http://link.springer.com/article/10.1186/s12917-018-1552-7 |
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