Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
Abstract Background Laryngeal paralysis is a disease process most commonly seen in older, large breed dogs. When both arytenoid cartilages are affected dogs can develop life-threatening respiratory compromise, therefore surgical intervention is recommended. While there are multiple surgical procedur...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-05-01
|
| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-022-03263-y |
| _version_ | 1811250904825856000 |
|---|---|
| author | Katelyn E. MacGillivray Sean D. Bellefeuille Daniel E. Hoffmann Lindsay L. St. Germaine |
| author_facet | Katelyn E. MacGillivray Sean D. Bellefeuille Daniel E. Hoffmann Lindsay L. St. Germaine |
| author_sort | Katelyn E. MacGillivray |
| collection | DOAJ |
| description | Abstract Background Laryngeal paralysis is a disease process most commonly seen in older, large breed dogs. When both arytenoid cartilages are affected dogs can develop life-threatening respiratory compromise, therefore surgical intervention is recommended. While there are multiple surgical procedures that have been described to treat laryngeal paralysis, there remains a considerable risk for postoperative complications, most commonly aspiration pneumonia. The objective of this ex vivo experimental study was to evaluate the effects of a novel, 3D printed bilateral arytenoid abductor on laryngeal airway resistance in canine cadaver larynges. Laryngeal airway resistance was calculated for each specimen before (control) and after placement of a 3D printed, bilateral arytenoid abductor. The airway resistance was measured at an airflow of 10 L/min with the epiglottis closed and at airflows ranging from 15 L/min to 60 L/min with the epiglottis open. The effects of the bilateral arytenoid abductor on laryngeal airway resistance were evaluated statistically. Results With the epiglottis open, median laryngeal airway resistance in all larynges with a bilateral arytenoid abductor were significantly decreased at airflows of 15 L/min (0.0cmH2O/L/sec), 30 L/min (0.2cmH2O/L/sec), and 45 L/min (0.2cmH2O/L/sec) compared to the controls 15 L/min (0.4cmH2O/L/sec; P = 0.04), 30 L/min (0.9cmH2O/L/sec; P = 0.04), and 45 L/min (1.2cmH2O/L/sec; P = 0.04). When the epiglottis was closed, there was no significant difference in laryngeal resistance between the control (18.8cmH2O/L/sec) and the abducted larynges (18.1cmH2O/L/sec; P = 0.83). Conclusions Placement of a bilateral arytenoid abductor reduced laryngeal resistance in canine cadaver larynges compared to the controls when the epiglottis was open. With the epiglottis closed, there was no loss of laryngeal resistance while the device abducted the arytenoid cartilages. The results of this ex vivo study is encouraging for consideration of further evaluation of the bilateral arytenoid abductor to determine an appropriate material and tolerance of this device in vivo. |
| first_indexed | 2024-04-12T16:11:44Z |
| format | Article |
| id | doaj.art-4bea5feac108419e83f86df0466d1d9c |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-04-12T16:11:44Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-4bea5feac108419e83f86df0466d1d9c2022-12-22T03:25:52ZengBMCBMC Veterinary Research1746-61482022-05-011811710.1186/s12917-022-03263-yEffects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivoKatelyn E. MacGillivray0Sean D. Bellefeuille1Daniel E. Hoffmann2Lindsay L. St. Germaine3Veterinary Specialists and Emergency ServicesDepartment of Biomedical Engineering, Rochester Institute of TechnologyVeterinary Specialists and Emergency ServicesVeterinary Specialists and Emergency ServicesAbstract Background Laryngeal paralysis is a disease process most commonly seen in older, large breed dogs. When both arytenoid cartilages are affected dogs can develop life-threatening respiratory compromise, therefore surgical intervention is recommended. While there are multiple surgical procedures that have been described to treat laryngeal paralysis, there remains a considerable risk for postoperative complications, most commonly aspiration pneumonia. The objective of this ex vivo experimental study was to evaluate the effects of a novel, 3D printed bilateral arytenoid abductor on laryngeal airway resistance in canine cadaver larynges. Laryngeal airway resistance was calculated for each specimen before (control) and after placement of a 3D printed, bilateral arytenoid abductor. The airway resistance was measured at an airflow of 10 L/min with the epiglottis closed and at airflows ranging from 15 L/min to 60 L/min with the epiglottis open. The effects of the bilateral arytenoid abductor on laryngeal airway resistance were evaluated statistically. Results With the epiglottis open, median laryngeal airway resistance in all larynges with a bilateral arytenoid abductor were significantly decreased at airflows of 15 L/min (0.0cmH2O/L/sec), 30 L/min (0.2cmH2O/L/sec), and 45 L/min (0.2cmH2O/L/sec) compared to the controls 15 L/min (0.4cmH2O/L/sec; P = 0.04), 30 L/min (0.9cmH2O/L/sec; P = 0.04), and 45 L/min (1.2cmH2O/L/sec; P = 0.04). When the epiglottis was closed, there was no significant difference in laryngeal resistance between the control (18.8cmH2O/L/sec) and the abducted larynges (18.1cmH2O/L/sec; P = 0.83). Conclusions Placement of a bilateral arytenoid abductor reduced laryngeal resistance in canine cadaver larynges compared to the controls when the epiglottis was open. With the epiglottis closed, there was no loss of laryngeal resistance while the device abducted the arytenoid cartilages. The results of this ex vivo study is encouraging for consideration of further evaluation of the bilateral arytenoid abductor to determine an appropriate material and tolerance of this device in vivo.https://doi.org/10.1186/s12917-022-03263-yLaryngeal paralysisLaryngeal airway resistanceArytenoid abductor |
| spellingShingle | Katelyn E. MacGillivray Sean D. Bellefeuille Daniel E. Hoffmann Lindsay L. St. Germaine Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo BMC Veterinary Research Laryngeal paralysis Laryngeal airway resistance Arytenoid abductor |
| title | Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo |
| title_full | Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo |
| title_fullStr | Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo |
| title_full_unstemmed | Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo |
| title_short | Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo |
| title_sort | effects of a novel 3d printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo |
| topic | Laryngeal paralysis Laryngeal airway resistance Arytenoid abductor |
| url | https://doi.org/10.1186/s12917-022-03263-y |
| work_keys_str_mv | AT katelynemacgillivray effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo AT seandbellefeuille effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo AT danielehoffmann effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo AT lindsaylstgermaine effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo |