Group A rotavirus genotypes and the ongoing Brazilian experience: a review
Brazil was the first Latin American country to introduce universal group A rotavirus (RV-A) vaccination in March 2006, resulting in a unique epidemiological scenario. Since RV-A first identification in Brazil, 2,691 RV-A-positive stool samples, collected between 1982- 2007, were typed by independent...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2008-12-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800001 |
| _version_ | 1797715704911233024 |
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| author | José Paulo Gagliardi Leite Filipe Anibal Carvalho-Costa Alexandre C Linhares |
| author_facet | José Paulo Gagliardi Leite Filipe Anibal Carvalho-Costa Alexandre C Linhares |
| author_sort | José Paulo Gagliardi Leite |
| collection | DOAJ |
| description | Brazil was the first Latin American country to introduce universal group A rotavirus (RV-A) vaccination in March 2006, resulting in a unique epidemiological scenario. Since RV-A first identification in Brazil, 2,691 RV-A-positive stool samples, collected between 1982- 2007, were typed by independent research groups throughout the country. In the pre-vaccination era, 2,492 RV-A-positive samples collected from 1982-2005 were successfully typed, while 199 samples were analyzed from 2006-2007. According to the reviewed studies, there were two important times in the pre-vaccination era: (i) the period from 1982-1995, during which the detection of G5P[8] RV-A, in addition to the classical genotypes G1-4, challenged vaccine development programs; and (ii) the period from 1996-2005, during which genotype G9P[8] emerged, following a global trend. The rate of G2P[4] RV-A detection decreased from 26% (173/653) during 1982-1995 to 2% (43/1,839) during 1996-2005. The overall detection rate of RV-A genotypes from 1982-2005 was as follows: 43% (n = 1,079) G1P[8]/G1P[not typed (NT)]; 20% (n = 488) G9P[8]/G9P[NT]; 9% (n = 216) G2P[4]/G2P[NT]; 6% (n = 151) G3P[8]/G3P[NT]; 4% (n = 103) G4P[8]/G4P[NT]; and 4% (n = 94) G5P[8]/G5P[NT]. Mixed infections accounted for 189 (7%) of the positive samples, while atypical G/P combinations or other genotypes, including G6, G8, G10 and G12, were identified in 172 (7%) samples. The initial surveillance studies carried out in several Brazilian states with RV-A-positive samples collected in 2006 and 2007 show a predominance of G2P[4] strains (148/199 or 74%). Herein, we review RV-A typing studies carried out since the 1980s in Brazil, highlighting the dynamics of RV-A strain circulation profiles before and early after universal use of RV-A vaccine in Brazil. |
| first_indexed | 2024-03-12T08:11:49Z |
| format | Article |
| id | doaj.art-4beb3898f2b04913924df8fab3601bad |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:49Z |
| publishDate | 2008-12-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-4beb3898f2b04913924df8fab3601bad2023-09-02T19:06:58ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602008-12-01103874575310.1590/S0074-02762008000800001Group A rotavirus genotypes and the ongoing Brazilian experience: a reviewJosé Paulo Gagliardi LeiteFilipe Anibal Carvalho-CostaAlexandre C LinharesBrazil was the first Latin American country to introduce universal group A rotavirus (RV-A) vaccination in March 2006, resulting in a unique epidemiological scenario. Since RV-A first identification in Brazil, 2,691 RV-A-positive stool samples, collected between 1982- 2007, were typed by independent research groups throughout the country. In the pre-vaccination era, 2,492 RV-A-positive samples collected from 1982-2005 were successfully typed, while 199 samples were analyzed from 2006-2007. According to the reviewed studies, there were two important times in the pre-vaccination era: (i) the period from 1982-1995, during which the detection of G5P[8] RV-A, in addition to the classical genotypes G1-4, challenged vaccine development programs; and (ii) the period from 1996-2005, during which genotype G9P[8] emerged, following a global trend. The rate of G2P[4] RV-A detection decreased from 26% (173/653) during 1982-1995 to 2% (43/1,839) during 1996-2005. The overall detection rate of RV-A genotypes from 1982-2005 was as follows: 43% (n = 1,079) G1P[8]/G1P[not typed (NT)]; 20% (n = 488) G9P[8]/G9P[NT]; 9% (n = 216) G2P[4]/G2P[NT]; 6% (n = 151) G3P[8]/G3P[NT]; 4% (n = 103) G4P[8]/G4P[NT]; and 4% (n = 94) G5P[8]/G5P[NT]. Mixed infections accounted for 189 (7%) of the positive samples, while atypical G/P combinations or other genotypes, including G6, G8, G10 and G12, were identified in 172 (7%) samples. The initial surveillance studies carried out in several Brazilian states with RV-A-positive samples collected in 2006 and 2007 show a predominance of G2P[4] strains (148/199 or 74%). Herein, we review RV-A typing studies carried out since the 1980s in Brazil, highlighting the dynamics of RV-A strain circulation profiles before and early after universal use of RV-A vaccine in Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800001rotavirusgenotypesvaccineBrazil |
| spellingShingle | José Paulo Gagliardi Leite Filipe Anibal Carvalho-Costa Alexandre C Linhares Group A rotavirus genotypes and the ongoing Brazilian experience: a review Memorias do Instituto Oswaldo Cruz rotavirus genotypes vaccine Brazil |
| title | Group A rotavirus genotypes and the ongoing Brazilian experience: a review |
| title_full | Group A rotavirus genotypes and the ongoing Brazilian experience: a review |
| title_fullStr | Group A rotavirus genotypes and the ongoing Brazilian experience: a review |
| title_full_unstemmed | Group A rotavirus genotypes and the ongoing Brazilian experience: a review |
| title_short | Group A rotavirus genotypes and the ongoing Brazilian experience: a review |
| title_sort | group a rotavirus genotypes and the ongoing brazilian experience a review |
| topic | rotavirus genotypes vaccine Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800001 |
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