Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome

Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome

Ectopic expression of MHC II molecules on glandular cells is a feature of primary Sjögren's syndrome (pSS). However, the cause of this ectopic expression and its potential role in the pathogenesis of the disease remains elusive. Here, we report that ectopic expression of MHC II molecules on gla...

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Bibliographic Details
Main Authors: Junping Yin, Junfeng Zheng, Fengyuan Deng, Wenjie Zhao, Yan Chen, Qiaoniang Huang, Renliang Huang, Lifang Wen, Xiaoyang Yue, Frank Petersen, Xinhua Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
primary Sjögren's syndrome
mouse model
presymptomatic feature
MHC II ectopic expression
TiterMax®
adjuvant
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02362/full

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