Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice
Recent studies have been demonstrated that neuroinflammation plays a crucial role in the pathophysiology of depression. Therefore, anti-inflammatory medications could be regarded as a potentially effective treatments for depression. Ellagic acid (EA) is a natural polyphenol with antioxidant and anti...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023027573 |
| _version_ | 1797836879362523136 |
|---|---|
| author | Zahra Mazrooei Hossein Tahmasebi Dehkordi Maryam Hashemi Shahraki Zahra Lorigooini Elham Zarean Hossein Amini-khoei |
| author_facet | Zahra Mazrooei Hossein Tahmasebi Dehkordi Maryam Hashemi Shahraki Zahra Lorigooini Elham Zarean Hossein Amini-khoei |
| author_sort | Zahra Mazrooei |
| collection | DOAJ |
| description | Recent studies have been demonstrated that neuroinflammation plays a crucial role in the pathophysiology of depression. Therefore, anti-inflammatory medications could be regarded as a potentially effective treatments for depression. Ellagic acid (EA) is a natural polyphenol with antioxidant and anti-inflammatory properties. This study aimed to evaluate the antidepressant-like effect of EA in a mouse model of social isolation stress (SIS), considering its potential anti-neuroinflammatory properties. In this study, 48 male mice were divided into six groups (n = 8), including saline-treated control (socially conditioned (SC)) group and SIS (isolation conditioned (IC)) groups treated with saline or EA at doses of 12.5, 25, 50, and 100 mg/kg, respectively. Saline and EA were administrated intraperitoneally for 14 constant days. Immobility time in the forced swimming test (FST) and grooming activity time in the splash test were measured. The gene expression of inflammatory cytokines relevant to neuroinflammation was assessed in the hippocampus by real-time PCR. Results showed that SIS significantly increased immobility time in the FST and reduced grooming activity time in the splash test. In addition, the expression of inflammatory genes, including TNF-α, IL-1β, and TLR4 increased in IC mice's hippocampi. Findings showed that EA decreased immobility time in the FST and increased grooming activity time in the splash test. Moreover, EA attenuated neuroimmune-response in the hippocampus. In conclusion, finding determined that EA, through attenuation of neuroinflammation in the hippocampus, partially at least, exerted an antidepressant-like effect in the mouse model of SIS. |
| first_indexed | 2024-04-09T15:17:02Z |
| format | Article |
| id | doaj.art-4beed831ded740ec8fad8b8dc5e4bec2 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:17:02Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4beed831ded740ec8fad8b8dc5e4bec22023-04-29T14:57:05ZengElsevierHeliyon2405-84402023-04-0194e15550Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated miceZahra Mazrooei0Hossein Tahmasebi Dehkordi1Maryam Hashemi Shahraki2Zahra Lorigooini3Elham Zarean4Hossein Amini-khoei5Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranCorresponding author.; Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranRecent studies have been demonstrated that neuroinflammation plays a crucial role in the pathophysiology of depression. Therefore, anti-inflammatory medications could be regarded as a potentially effective treatments for depression. Ellagic acid (EA) is a natural polyphenol with antioxidant and anti-inflammatory properties. This study aimed to evaluate the antidepressant-like effect of EA in a mouse model of social isolation stress (SIS), considering its potential anti-neuroinflammatory properties. In this study, 48 male mice were divided into six groups (n = 8), including saline-treated control (socially conditioned (SC)) group and SIS (isolation conditioned (IC)) groups treated with saline or EA at doses of 12.5, 25, 50, and 100 mg/kg, respectively. Saline and EA were administrated intraperitoneally for 14 constant days. Immobility time in the forced swimming test (FST) and grooming activity time in the splash test were measured. The gene expression of inflammatory cytokines relevant to neuroinflammation was assessed in the hippocampus by real-time PCR. Results showed that SIS significantly increased immobility time in the FST and reduced grooming activity time in the splash test. In addition, the expression of inflammatory genes, including TNF-α, IL-1β, and TLR4 increased in IC mice's hippocampi. Findings showed that EA decreased immobility time in the FST and increased grooming activity time in the splash test. Moreover, EA attenuated neuroimmune-response in the hippocampus. In conclusion, finding determined that EA, through attenuation of neuroinflammation in the hippocampus, partially at least, exerted an antidepressant-like effect in the mouse model of SIS.http://www.sciencedirect.com/science/article/pii/S2405844023027573Ellagic acidSocial isolation stressNeuroinflammationDepression |
| spellingShingle | Zahra Mazrooei Hossein Tahmasebi Dehkordi Maryam Hashemi Shahraki Zahra Lorigooini Elham Zarean Hossein Amini-khoei Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice Heliyon Ellagic acid Social isolation stress Neuroinflammation Depression |
| title | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| title_full | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| title_fullStr | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| title_full_unstemmed | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| title_short | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| title_sort | ellagic acid through attenuation of neuro inflammatory response exerted antidepressant like effects in socially isolated mice |
| topic | Ellagic acid Social isolation stress Neuroinflammation Depression |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023027573 |
| work_keys_str_mv | AT zahramazrooei ellagicacidthroughattenuationofneuroinflammatoryresponseexertedantidepressantlikeeffectsinsociallyisolatedmice AT hosseintahmasebidehkordi ellagicacidthroughattenuationofneuroinflammatoryresponseexertedantidepressantlikeeffectsinsociallyisolatedmice AT maryamhashemishahraki ellagicacidthroughattenuationofneuroinflammatoryresponseexertedantidepressantlikeeffectsinsociallyisolatedmice AT zahralorigooini ellagicacidthroughattenuationofneuroinflammatoryresponseexertedantidepressantlikeeffectsinsociallyisolatedmice AT elhamzarean ellagicacidthroughattenuationofneuroinflammatoryresponseexertedantidepressantlikeeffectsinsociallyisolatedmice AT hosseinaminikhoei ellagicacidthroughattenuationofneuroinflammatoryresponseexertedantidepressantlikeeffectsinsociallyisolatedmice |