Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers
Sepsis and sepsis-related organ dysfunction have been identified as significant global life-threatening health threats, with a high mortality rate despite ongoing research in the area. Timely diagnosis is essential such that treatment could be initiated as early as possible to ensure the best outcom...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-01-01
|
| Series: | Smart Materials in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590183423000248 |
| _version_ | 1827895773266706432 |
|---|---|
| author | Roushka Bhagwan Valjee Usri H. Ibrahim Kwanele Xulu Saajida Mahomed Irene Mackraj |
| author_facet | Roushka Bhagwan Valjee Usri H. Ibrahim Kwanele Xulu Saajida Mahomed Irene Mackraj |
| author_sort | Roushka Bhagwan Valjee |
| collection | DOAJ |
| description | Sepsis and sepsis-related organ dysfunction have been identified as significant global life-threatening health threats, with a high mortality rate despite ongoing research in the area. Timely diagnosis is essential such that treatment could be initiated as early as possible to ensure the best outcome, since delayed intervention is associated with a higher mortality. Patient stratification and disease monitoring, present significant challenges in sepsis treatment and management strategies, largely due to the heterogenicity of sepsis signs and symptoms. Hence a focus on potential biomarkers to overcome these challenges is needed. Recently, extracellular vesicles (EVs), mainly the exosome subtype, have been investigated regarding their potential role in sepsis diagnostics, therapeutics and as drug delivery vehicles. Herein, we present an up-to-date review covering the role of circulating exosomes in the diagnosis and monitoring of the progression of sepsis and in therapeutics and drug delivery for sepsis. To provide context, sepsis pathophysiology and the role of circulating exosomes in sepsis have been highlighted. Future prospects, current challenges and recommendations regarding the role of exosomes in sepsis are also identified. |
| first_indexed | 2024-03-12T22:25:33Z |
| format | Article |
| id | doaj.art-4bf03df4e4c84249b7b66c151c29b2e0 |
| institution | Directory Open Access Journal |
| issn | 2590-1834 |
| language | English |
| last_indexed | 2024-03-12T22:25:33Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Smart Materials in Medicine |
| spelling | doaj.art-4bf03df4e4c84249b7b66c151c29b2e02023-07-22T04:52:49ZengKeAi Communications Co., Ltd.Smart Materials in Medicine2590-18342023-01-014639647Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriersRoushka Bhagwan Valjee0Usri H. Ibrahim1Kwanele Xulu2Saajida Mahomed3Irene Mackraj4Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South AfricaDiscipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Corresponding author.Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South AfricaDiscipline of Public Health, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South AfricaDiscipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Corresponding author.Sepsis and sepsis-related organ dysfunction have been identified as significant global life-threatening health threats, with a high mortality rate despite ongoing research in the area. Timely diagnosis is essential such that treatment could be initiated as early as possible to ensure the best outcome, since delayed intervention is associated with a higher mortality. Patient stratification and disease monitoring, present significant challenges in sepsis treatment and management strategies, largely due to the heterogenicity of sepsis signs and symptoms. Hence a focus on potential biomarkers to overcome these challenges is needed. Recently, extracellular vesicles (EVs), mainly the exosome subtype, have been investigated regarding their potential role in sepsis diagnostics, therapeutics and as drug delivery vehicles. Herein, we present an up-to-date review covering the role of circulating exosomes in the diagnosis and monitoring of the progression of sepsis and in therapeutics and drug delivery for sepsis. To provide context, sepsis pathophysiology and the role of circulating exosomes in sepsis have been highlighted. Future prospects, current challenges and recommendations regarding the role of exosomes in sepsis are also identified.http://www.sciencedirect.com/science/article/pii/S2590183423000248SepsisExosomesDiagnosticsDrug deliveryTherapeutics |
| spellingShingle | Roushka Bhagwan Valjee Usri H. Ibrahim Kwanele Xulu Saajida Mahomed Irene Mackraj Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers Smart Materials in Medicine Sepsis Exosomes Diagnostics Drug delivery Therapeutics |
| title | Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers |
| title_full | Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers |
| title_fullStr | Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers |
| title_full_unstemmed | Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers |
| title_short | Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers |
| title_sort | circulating exosomes in sepsis a potential role as diagnostic biomarkers therapeutic and drug delivery carriers |
| topic | Sepsis Exosomes Diagnostics Drug delivery Therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2590183423000248 |
| work_keys_str_mv | AT roushkabhagwanvaljee circulatingexosomesinsepsisapotentialroleasdiagnosticbiomarkerstherapeuticanddrugdeliverycarriers AT usrihibrahim circulatingexosomesinsepsisapotentialroleasdiagnosticbiomarkerstherapeuticanddrugdeliverycarriers AT kwanelexulu circulatingexosomesinsepsisapotentialroleasdiagnosticbiomarkerstherapeuticanddrugdeliverycarriers AT saajidamahomed circulatingexosomesinsepsisapotentialroleasdiagnosticbiomarkerstherapeuticanddrugdeliverycarriers AT irenemackraj circulatingexosomesinsepsisapotentialroleasdiagnosticbiomarkerstherapeuticanddrugdeliverycarriers |