Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective Study
Jie-Ying Wan, Li-Zhen Yang Division of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of ChinaCorrespondence: Li-Zhen Yang, Tel +86-15618690375, Email dryanginsh@sina.comPurpose: The correlation be...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/liver-enzymes-are-associated-with-hyperglycemia-in-diabetes-a-three-ye-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1828046927755739136 |
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| author | Wan JY Yang LZ |
| author_facet | Wan JY Yang LZ |
| author_sort | Wan JY |
| collection | DOAJ |
| description | Jie-Ying Wan, Li-Zhen Yang Division of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of ChinaCorrespondence: Li-Zhen Yang, Tel +86-15618690375, Email dryanginsh@sina.comPurpose: The correlation between liver enzymes and blood glucose in diabetes mellitus remains unclear. The purpose of present three-year retrospective study was to explore the association between liver enzymes and glycemia in type 2 diabetes mellitus (T2DM).Patients and Methods: 2046 participants (non-fatty liver, n=1253; fatty liver, n=793) with T2DM were included in our study. For all these patients, related basic clinical information, biochemical parameters and liver ultrasonic data were collected. The effects of liver enzymes on blood glucose levels were analysed by linear and binary logistic regression models.Results: In the comparative analyses between groups, gamma-glutamyltransferase (GGT) and serum alkaline phosphatase (AKP) levels increased with glycosylated haemoglobin A1c (HbA1c) concentration, but alanine aminotransferase and aspartate aminotransferase did not show the same trend. Adjusted for possible confounding factors, the linear regression models indicated the strong positive correlations between Log10 AKP, Log10 GGT and three blood glucose parameters (fasting glucose, postprandial glucose, and HbA1c) (all P< 0.01). And such correlations were more significant in the subgroups of fatty liver. Multivariate binary logistic regression showed that the ORs increased by 1.01 times higher per Log10 AKP unit in the highest blood glucose tertile (P< 0.01).Conclusion: GGT and especially AKP can aggravate hyperglycemia in T2DM patients, which provides new clues for the research and treatment of T2DM.Keywords: liver enzymes, fasting blood glucose, postprandial blood glucose, HbA1c, T2DM |
| first_indexed | 2024-04-10T18:33:00Z |
| format | Article |
| id | doaj.art-4bf068488df14571bb83a1c5dd2dce9c |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:33:00Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-4bf068488df14571bb83a1c5dd2dce9c2023-02-02T02:37:18ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-02-01Volume 1554555573158Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective StudyWan JYYang LZJie-Ying Wan, Li-Zhen Yang Division of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of ChinaCorrespondence: Li-Zhen Yang, Tel +86-15618690375, Email dryanginsh@sina.comPurpose: The correlation between liver enzymes and blood glucose in diabetes mellitus remains unclear. The purpose of present three-year retrospective study was to explore the association between liver enzymes and glycemia in type 2 diabetes mellitus (T2DM).Patients and Methods: 2046 participants (non-fatty liver, n=1253; fatty liver, n=793) with T2DM were included in our study. For all these patients, related basic clinical information, biochemical parameters and liver ultrasonic data were collected. The effects of liver enzymes on blood glucose levels were analysed by linear and binary logistic regression models.Results: In the comparative analyses between groups, gamma-glutamyltransferase (GGT) and serum alkaline phosphatase (AKP) levels increased with glycosylated haemoglobin A1c (HbA1c) concentration, but alanine aminotransferase and aspartate aminotransferase did not show the same trend. Adjusted for possible confounding factors, the linear regression models indicated the strong positive correlations between Log10 AKP, Log10 GGT and three blood glucose parameters (fasting glucose, postprandial glucose, and HbA1c) (all P< 0.01). And such correlations were more significant in the subgroups of fatty liver. Multivariate binary logistic regression showed that the ORs increased by 1.01 times higher per Log10 AKP unit in the highest blood glucose tertile (P< 0.01).Conclusion: GGT and especially AKP can aggravate hyperglycemia in T2DM patients, which provides new clues for the research and treatment of T2DM.Keywords: liver enzymes, fasting blood glucose, postprandial blood glucose, HbA1c, T2DMhttps://www.dovepress.com/liver-enzymes-are-associated-with-hyperglycemia-in-diabetes-a-three-ye-peer-reviewed-fulltext-article-DMSOliver enzymesfasting blood glucosepostprandial blood glucosehba1ct2dm |
| spellingShingle | Wan JY Yang LZ Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective Study Diabetes, Metabolic Syndrome and Obesity liver enzymes fasting blood glucose postprandial blood glucose hba1c t2dm |
| title | Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective Study |
| title_full | Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective Study |
| title_fullStr | Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective Study |
| title_full_unstemmed | Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective Study |
| title_short | Liver Enzymes are Associated with Hyperglycemia in Diabetes: A Three-Year Retrospective Study |
| title_sort | liver enzymes are associated with hyperglycemia in diabetes a three year retrospective study |
| topic | liver enzymes fasting blood glucose postprandial blood glucose hba1c t2dm |
| url | https://www.dovepress.com/liver-enzymes-are-associated-with-hyperglycemia-in-diabetes-a-three-ye-peer-reviewed-fulltext-article-DMSO |
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