Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative review
Abstract Obesity is a public health crisis, presenting a huge burden on health care and the economic system in both developed and developing countries. According to the WHO’s latest report on obesity, 39% of adults of age 18 and above are obese, with an increase of 18% compared to the last few decad...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-10-01
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| Series: | Eating and Weight Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40519-023-01593-w |
| _version_ | 1797454076892413952 |
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| author | Weiming Wu Zhengfang Chen Jiani Han Lingling Qian Wanqiu Wang Jiacai Lei Huaguan Wang |
| author_facet | Weiming Wu Zhengfang Chen Jiani Han Lingling Qian Wanqiu Wang Jiacai Lei Huaguan Wang |
| author_sort | Weiming Wu |
| collection | DOAJ |
| description | Abstract Obesity is a public health crisis, presenting a huge burden on health care and the economic system in both developed and developing countries. According to the WHO’s latest report on obesity, 39% of adults of age 18 and above are obese, with an increase of 18% compared to the last few decades. Metabolic energy imbalance due to contemporary lifestyle, changes in gut microbiota, hormonal imbalance, inherent genetics, and epigenetics is a major contributory factor to this crisis. Multiple studies have shown that probiotics and their metabolites (postbiotics) supplementation have an effect on obesity-related effects in vitro, in vivo, and in human clinical investigations. Postbiotics such as the SCFAs suppress obesity by regulating metabolic hormones such as GLP-1, and PPY thus reducing feed intake and suppressing appetite. Furthermore, muramyl di-peptides, bacteriocins, and LPS have been tested against obesity and yielded promising results in both human and mice studies. These insights provide an overview of targetable pharmacological sites and explore new opportunities for the safer use of postbiotics against obesity in the future. |
| first_indexed | 2024-03-09T15:32:01Z |
| format | Article |
| id | doaj.art-4bf20fc2f242482f99f86b4da8fe62a0 |
| institution | Directory Open Access Journal |
| issn | 1590-1262 |
| language | English |
| last_indexed | 2024-03-09T15:32:01Z |
| publishDate | 2023-10-01 |
| publisher | Springer |
| record_format | Article |
| series | Eating and Weight Disorders |
| spelling | doaj.art-4bf20fc2f242482f99f86b4da8fe62a02023-11-26T12:09:36ZengSpringerEating and Weight Disorders1590-12622023-10-0128111710.1007/s40519-023-01593-wEndocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative reviewWeiming Wu0Zhengfang Chen1Jiani Han2Lingling Qian3Wanqiu Wang4Jiacai Lei5Huaguan Wang6Department of Endocrinology, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Endocrinology, Changshu First People’s HospitalDepartment of Endocrinology, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Endocrinology, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Endocrinology, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Gastroenterology, Hangzhou Ninth People’s HospitalDepartment of Gastroenterology, Hangzhou Ninth People’s HospitalAbstract Obesity is a public health crisis, presenting a huge burden on health care and the economic system in both developed and developing countries. According to the WHO’s latest report on obesity, 39% of adults of age 18 and above are obese, with an increase of 18% compared to the last few decades. Metabolic energy imbalance due to contemporary lifestyle, changes in gut microbiota, hormonal imbalance, inherent genetics, and epigenetics is a major contributory factor to this crisis. Multiple studies have shown that probiotics and their metabolites (postbiotics) supplementation have an effect on obesity-related effects in vitro, in vivo, and in human clinical investigations. Postbiotics such as the SCFAs suppress obesity by regulating metabolic hormones such as GLP-1, and PPY thus reducing feed intake and suppressing appetite. Furthermore, muramyl di-peptides, bacteriocins, and LPS have been tested against obesity and yielded promising results in both human and mice studies. These insights provide an overview of targetable pharmacological sites and explore new opportunities for the safer use of postbiotics against obesity in the future.https://doi.org/10.1007/s40519-023-01593-wObesityEnergy metabolismGut microbiomePostbioticsSCFAsMuramyl di-peptides |
| spellingShingle | Weiming Wu Zhengfang Chen Jiani Han Lingling Qian Wanqiu Wang Jiacai Lei Huaguan Wang Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative review Eating and Weight Disorders Obesity Energy metabolism Gut microbiome Postbiotics SCFAs Muramyl di-peptides |
| title | Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative review |
| title_full | Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative review |
| title_fullStr | Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative review |
| title_full_unstemmed | Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative review |
| title_short | Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: a narrative review |
| title_sort | endocrine genetic and microbiome nexus of obesity and potential role of postbiotics a narrative review |
| topic | Obesity Energy metabolism Gut microbiome Postbiotics SCFAs Muramyl di-peptides |
| url | https://doi.org/10.1007/s40519-023-01593-w |
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