Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility
Abstract Background Hypermobility is a poorly recognised and understood musculoskeletal disorder thought to affect around 20% of the population. Hypermobility is associated with reduced physiological and psychological functioning and quality of life and is a known risk factor for the development of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Trials |
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| Online Access: | https://doi.org/10.1186/s13063-021-05555-4 |
| _version_ | 1819111083788468224 |
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| author | Geoff Davies Jenny L. L. Csecs Heather Ball Jess Dare Stephen Bremner Robin Hosking Hugo D. Critchley Nick Grey Jessica A. Eccles |
| author_facet | Geoff Davies Jenny L. L. Csecs Heather Ball Jess Dare Stephen Bremner Robin Hosking Hugo D. Critchley Nick Grey Jessica A. Eccles |
| author_sort | Geoff Davies |
| collection | DOAJ |
| description | Abstract Background Hypermobility is a poorly recognised and understood musculoskeletal disorder thought to affect around 20% of the population. Hypermobility is associated with reduced physiological and psychological functioning and quality of life and is a known risk factor for the development of an anxiety disorder. To date, no evidence-based, targeted treatment for anxiety in the context of hypermobility exists. The present intervention (ADAPT—Altering Dynamics of Autonomic Processing Therapy) is a novel therapy combining bio-behavioural training with cognitive approaches from clinical health psychology targeting the catastrophisation of internal sensations, with aim to improve autonomic trait prediction error. Method Eighty individuals with diagnosed hypermobility will be recruited and the efficacy of ADAPT to treat anxiety will be compared to an Emotion-Focused Supportive Therapy (EFST) comparator therapy in a randomised controlled trial. The primary treatment target will be post therapy score on the Beck Anxiety Inventory, and secondary outcomes will also be considered in relation to interoception, depression, alexithymia, social and work adjustment, panic symptoms and dissociation. Due to COVID restrictions, the intervention will be moved to online delivery and qualitative assessment of treatment tolerance to online therapy will also be assessed. Discussion Online delivery of an intervention targeting anxiety would improve the quality of life for those experiencing anxiety disorder and help to reduce the £11.7 billion that anxiety disorders cost the UK economy annually. Trial registration World Health Organization ISRCTN17018615 . Registered on 20th February 2019; trial protocol version 2 |
| first_indexed | 2024-12-22T03:51:59Z |
| format | Article |
| id | doaj.art-4bf57ec815644b5ab7e8a028a0f0e470 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-22T03:51:59Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-4bf57ec815644b5ab7e8a028a0f0e4702022-12-21T18:39:58ZengBMCTrials1745-62152021-09-0122111010.1186/s13063-021-05555-4Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobilityGeoff Davies0Jenny L. L. Csecs1Heather Ball2Jess Dare3Stephen Bremner4Robin Hosking5Hugo D. Critchley6Nick Grey7Jessica A. Eccles8Department of Neuroscience, Brighton and Sussex Medical School, University of SussexDepartment of Neuroscience, Brighton and Sussex Medical School, University of SussexSussex Partnership NHS Foundation TrustSussex Community NHS Foundation TrustBrighton and Sussex Clinical Trials Unit, Brighton & Sussex Medical SchoolSussex Partnership NHS Foundation TrustDepartment of Neuroscience, Brighton and Sussex Medical School, University of SussexSussex Partnership NHS Foundation TrustDepartment of Neuroscience, Brighton and Sussex Medical School, University of SussexAbstract Background Hypermobility is a poorly recognised and understood musculoskeletal disorder thought to affect around 20% of the population. Hypermobility is associated with reduced physiological and psychological functioning and quality of life and is a known risk factor for the development of an anxiety disorder. To date, no evidence-based, targeted treatment for anxiety in the context of hypermobility exists. The present intervention (ADAPT—Altering Dynamics of Autonomic Processing Therapy) is a novel therapy combining bio-behavioural training with cognitive approaches from clinical health psychology targeting the catastrophisation of internal sensations, with aim to improve autonomic trait prediction error. Method Eighty individuals with diagnosed hypermobility will be recruited and the efficacy of ADAPT to treat anxiety will be compared to an Emotion-Focused Supportive Therapy (EFST) comparator therapy in a randomised controlled trial. The primary treatment target will be post therapy score on the Beck Anxiety Inventory, and secondary outcomes will also be considered in relation to interoception, depression, alexithymia, social and work adjustment, panic symptoms and dissociation. Due to COVID restrictions, the intervention will be moved to online delivery and qualitative assessment of treatment tolerance to online therapy will also be assessed. Discussion Online delivery of an intervention targeting anxiety would improve the quality of life for those experiencing anxiety disorder and help to reduce the £11.7 billion that anxiety disorders cost the UK economy annually. Trial registration World Health Organization ISRCTN17018615 . Registered on 20th February 2019; trial protocol version 2https://doi.org/10.1186/s13063-021-05555-4HypermobilityAnxietyCBTInteroceptionRCT |
| spellingShingle | Geoff Davies Jenny L. L. Csecs Heather Ball Jess Dare Stephen Bremner Robin Hosking Hugo D. Critchley Nick Grey Jessica A. Eccles Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility Trials Hypermobility Anxiety CBT Interoception RCT |
| title | Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility |
| title_full | Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility |
| title_fullStr | Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility |
| title_full_unstemmed | Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility |
| title_short | Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility |
| title_sort | altering dynamics of autonomic processing therapy adapt trial a novel targeted treatment for reducing anxiety in joint hypermobility |
| topic | Hypermobility Anxiety CBT Interoception RCT |
| url | https://doi.org/10.1186/s13063-021-05555-4 |
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