The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses
A significant increase in the number of viruses causing unexpected illnesses and epidemics among humans, wildlife and livestock has been observed in recent years. These new or re-emerging viruses have often caught the scientific community off-guard, without sufficient knowledge to combat them, as sh...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/9/1766 |
| _version_ | 1797516986084753408 |
|---|---|
| author | Alexandra Serris |
| author_facet | Alexandra Serris |
| author_sort | Alexandra Serris |
| collection | DOAJ |
| description | A significant increase in the number of viruses causing unexpected illnesses and epidemics among humans, wildlife and livestock has been observed in recent years. These new or re-emerging viruses have often caught the scientific community off-guard, without sufficient knowledge to combat them, as shown by the current coronavirus pandemic. The bunyaviruses, together with the flaviviruses and filoviruses, are the major etiological agents of viral hemorrhagic fever, and several of them have been listed as priority pathogens by the World Health Organization for which insufficient countermeasures exist. Based on new techniques allowing rapid analysis of the repertoire of protective antibodies induced during infection, combined with atomic-level structural information on viral surface proteins, structural vaccinology is now instrumental in the combat against newly emerging threats, as it allows rapid rational design of novel vaccine antigens. Here, we discuss the contribution of structural vaccinology and the current challenges that remain in the search for an efficient vaccine against some of the deadliest bunyaviruses. |
| first_indexed | 2024-03-10T07:08:32Z |
| format | Article |
| id | doaj.art-4bf720dc5cca452883fe66839653c6f0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:08:32Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4bf720dc5cca452883fe66839653c6f02023-11-22T15:37:41ZengMDPI AGViruses1999-49152021-09-01139176610.3390/v13091766The Input of Structural Vaccinology in the Search for Vaccines against BunyavirusesAlexandra Serris0Department of Infectious Diseases and Tropical Medicine, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique—Hôpitaux de Paris, Université de Paris, 75015 Paris, FranceA significant increase in the number of viruses causing unexpected illnesses and epidemics among humans, wildlife and livestock has been observed in recent years. These new or re-emerging viruses have often caught the scientific community off-guard, without sufficient knowledge to combat them, as shown by the current coronavirus pandemic. The bunyaviruses, together with the flaviviruses and filoviruses, are the major etiological agents of viral hemorrhagic fever, and several of them have been listed as priority pathogens by the World Health Organization for which insufficient countermeasures exist. Based on new techniques allowing rapid analysis of the repertoire of protective antibodies induced during infection, combined with atomic-level structural information on viral surface proteins, structural vaccinology is now instrumental in the combat against newly emerging threats, as it allows rapid rational design of novel vaccine antigens. Here, we discuss the contribution of structural vaccinology and the current challenges that remain in the search for an efficient vaccine against some of the deadliest bunyaviruses.https://www.mdpi.com/1999-4915/13/9/1766bunyavirusstructural vaccinologyhantavirusphlebovirusnairovirusneutralizing antibodies |
| spellingShingle | Alexandra Serris The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses Viruses bunyavirus structural vaccinology hantavirus phlebovirus nairovirus neutralizing antibodies |
| title | The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses |
| title_full | The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses |
| title_fullStr | The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses |
| title_full_unstemmed | The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses |
| title_short | The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses |
| title_sort | input of structural vaccinology in the search for vaccines against bunyaviruses |
| topic | bunyavirus structural vaccinology hantavirus phlebovirus nairovirus neutralizing antibodies |
| url | https://www.mdpi.com/1999-4915/13/9/1766 |
| work_keys_str_mv | AT alexandraserris theinputofstructuralvaccinologyinthesearchforvaccinesagainstbunyaviruses AT alexandraserris inputofstructuralvaccinologyinthesearchforvaccinesagainstbunyaviruses |