Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus
The authors’ data and those from literature concerning biological role of fetuin A glycoprotein have been generalized in the article. A direct correlation has been established between fetuin A and some adipokines involved in the formation of insulin resistance and atherogenesis (progranulin, omenti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2013-06-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Gorshunska_3_13.pdf |
| _version_ | 1797428301273235456 |
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| author | M. Yu. Gorshunska Y. I. Karachentsev N. A. Kravchun E. Jansen3 Zh. A. Leshchenko A. I. Gladkih N. S. Krasova T. V. Tyzhnenko Y. A. Opaleyko V. V. Роltorak |
| author_facet | M. Yu. Gorshunska Y. I. Karachentsev N. A. Kravchun E. Jansen3 Zh. A. Leshchenko A. I. Gladkih N. S. Krasova T. V. Tyzhnenko Y. A. Opaleyko V. V. Роltorak |
| author_sort | M. Yu. Gorshunska |
| collection | DOAJ |
| description | The authors’ data and those from literature concerning biological role of fetuin A glycoprotein have been generalized in the article. A direct correlation has been established between fetuin A and some adipokines involved in the formation of insulin resistance and atherogenesis (progranulin, omentin-1), and osteoprotegerin (the novel cardiovascular risk factor) as well as an increase of circulating levels of fetuin A in patients with type 2 diabetes mellitus with high cardiovascular risk metabolic pattern but without manifestations of macrovascular complications. This substantiates the involvement of fetuin A in the complex of biomarkers of subclinical atherosclerosis. |
| first_indexed | 2024-03-09T08:56:03Z |
| format | Article |
| id | doaj.art-4bf736ae8fa74e4b90b7ef8c48784c92 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:56:03Z |
| publishDate | 2013-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-4bf736ae8fa74e4b90b7ef8c48784c922023-12-02T12:56:57ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032013-06-01853102110.15407/ubj85.03.010Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitusM. Yu. Gorshunska0Y. I. Karachentsev1N. A. Kravchun2E. Jansen33Zh. A. Leshchenko4A. I. Gladkih5N. S. Krasova6T. V. Tyzhnenko7Y. A. Opaleyko8V. V. Роltorak9Kharkiv Postgraduate Medical Academy,UkraineKharkiv Postgraduate Medical Academy,Ukraine; SI V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, KharkivNational Institute for Public Health and the Environment, Bilthoven, NetherlandsSI V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, KharkivSI V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, KharkivSI V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, KharkivSI V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, KharkivSI V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, KharkivSI V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, KharkivThe authors’ data and those from literature concerning biological role of fetuin A glycoprotein have been generalized in the article. A direct correlation has been established between fetuin A and some adipokines involved in the formation of insulin resistance and atherogenesis (progranulin, omentin-1), and osteoprotegerin (the novel cardiovascular risk factor) as well as an increase of circulating levels of fetuin A in patients with type 2 diabetes mellitus with high cardiovascular risk metabolic pattern but without manifestations of macrovascular complications. This substantiates the involvement of fetuin A in the complex of biomarkers of subclinical atherosclerosis.http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Gorshunska_3_13.pdfadipokinesatherosclerosiscardiovascular riskfetuin Ainsulin resistancetype 2 diabetes mellitus |
| spellingShingle | M. Yu. Gorshunska Y. I. Karachentsev N. A. Kravchun E. Jansen3 Zh. A. Leshchenko A. I. Gladkih N. S. Krasova T. V. Tyzhnenko Y. A. Opaleyko V. V. Роltorak Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus The Ukrainian Biochemical Journal adipokines atherosclerosis cardiovascular risk fetuin A insulin resistance type 2 diabetes mellitus |
| title | Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus |
| title_full | Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus |
| title_fullStr | Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus |
| title_short | Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus |
| title_sort | biological role of fetuin a and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus |
| topic | adipokines atherosclerosis cardiovascular risk fetuin A insulin resistance type 2 diabetes mellitus |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Gorshunska_3_13.pdf |
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