Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study
IntroductionTo allow the identification of IgG4-related disease (IgG4-RD) from a subclinical phase as it is important to understand the risk of elevated serum IgG4 levels. We planned to evaluate serum IgG4 levels in the participants of the Nagasaki Islands Study (NaIS), a large-scale health checkup...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124417/full |
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| author | Yoshika Tsuji Tomohiro Koga Tomohiro Koga Fumiaki Nonaka Kenichi Nobusue Shin-ya Kawashiri Hirotomo Yamanashi Takahiro Maeda Takahiro Maeda Kazuhiko Arima Kazuhiko Arima Kiyoshi Aoyagi Kiyoshi Aoyagi Meiko Takahashi Shuji Kawaguchi Fumihiko Matsuda Hiroshi Fujii Mitsuhiro Kawano Hiroyuki Nakamura Atsushi Kawakami Atsushi Kawakami Mami Tamai Mami Tamai |
| author_facet | Yoshika Tsuji Tomohiro Koga Tomohiro Koga Fumiaki Nonaka Kenichi Nobusue Shin-ya Kawashiri Hirotomo Yamanashi Takahiro Maeda Takahiro Maeda Kazuhiko Arima Kazuhiko Arima Kiyoshi Aoyagi Kiyoshi Aoyagi Meiko Takahashi Shuji Kawaguchi Fumihiko Matsuda Hiroshi Fujii Mitsuhiro Kawano Hiroyuki Nakamura Atsushi Kawakami Atsushi Kawakami Mami Tamai Mami Tamai |
| author_sort | Yoshika Tsuji |
| collection | DOAJ |
| description | IntroductionTo allow the identification of IgG4-related disease (IgG4-RD) from a subclinical phase as it is important to understand the risk of elevated serum IgG4 levels. We planned to evaluate serum IgG4 levels in the participants of the Nagasaki Islands Study (NaIS), a large-scale health checkup cohort study.MethodsThis study included 3,240 individuals who participated in the NaIS between 2016 and 2018 and consented to participate in the study. Serum IgG4, IgG, and IgE levels and human leukocyte antigen (HLA) genotyping results of the NaIS subjects as well as lifestyle habits and peripheral blood test results were analyzed. The magnetic bead panel assay (MBA) and the standard nephelometry immunoassay (NIA) were used to measure serum IgG4 levels. The data were evaluated using multivariate analysis to identify lifestyle and genetic factors associated with elevated serum IgG4 levels.ResultsSerum IgG4 levels measured with the NIA and MBA showed a tight positive correlation between the two groups (correlation coefficient 0.942). The median age of the participants in the NaIS was 69 years [63–77]. The median serum IgG4 level was 30.2 mg/dL [IQR 12.5–59.8]. Overall, 1019 (32.1%) patients had a history of smoking. When the subjects were stratified into three groups based on the smoking intensity (pack-year), the serum IgG4 level was significantly higher among those with a higher smoking intensity. Accordingly, the multivariate analysis identified a significant relationship between smoking status and serum IgG4 elevation.ConclusionIn this study, smoking was identified as a lifestyle factor correlating positively with elevated serum IgG4 levels. |
| first_indexed | 2024-04-10T05:22:17Z |
| format | Article |
| id | doaj.art-4bf910cb9611427fb3240ca74b822ee6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T05:22:17Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-4bf910cb9611427fb3240ca74b822ee62023-03-08T06:08:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11244171124417Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort studyYoshika Tsuji0Tomohiro Koga1Tomohiro Koga2Fumiaki Nonaka3Kenichi Nobusue4Shin-ya Kawashiri5Hirotomo Yamanashi6Takahiro Maeda7Takahiro Maeda8Kazuhiko Arima9Kazuhiko Arima10Kiyoshi Aoyagi11Kiyoshi Aoyagi12Meiko Takahashi13Shuji Kawaguchi14Fumihiko Matsuda15Hiroshi Fujii16Mitsuhiro Kawano17Hiroyuki Nakamura18Atsushi Kawakami19Atsushi Kawakami20Mami Tamai21Mami Tamai22Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanCenter for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of Island and Community Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of Island and Community Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of Community Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of General Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of General Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of Public Health, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of Public Health, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, JapanCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, JapanCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, JapanDivision of Rheumatology, Department of Internal Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, JapanDivision of Rheumatology, Department of Internal Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan0Department of Hygiene and Public Health, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, JapanDepartment of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanDepartment of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki, JapanIntroductionTo allow the identification of IgG4-related disease (IgG4-RD) from a subclinical phase as it is important to understand the risk of elevated serum IgG4 levels. We planned to evaluate serum IgG4 levels in the participants of the Nagasaki Islands Study (NaIS), a large-scale health checkup cohort study.MethodsThis study included 3,240 individuals who participated in the NaIS between 2016 and 2018 and consented to participate in the study. Serum IgG4, IgG, and IgE levels and human leukocyte antigen (HLA) genotyping results of the NaIS subjects as well as lifestyle habits and peripheral blood test results were analyzed. The magnetic bead panel assay (MBA) and the standard nephelometry immunoassay (NIA) were used to measure serum IgG4 levels. The data were evaluated using multivariate analysis to identify lifestyle and genetic factors associated with elevated serum IgG4 levels.ResultsSerum IgG4 levels measured with the NIA and MBA showed a tight positive correlation between the two groups (correlation coefficient 0.942). The median age of the participants in the NaIS was 69 years [63–77]. The median serum IgG4 level was 30.2 mg/dL [IQR 12.5–59.8]. Overall, 1019 (32.1%) patients had a history of smoking. When the subjects were stratified into three groups based on the smoking intensity (pack-year), the serum IgG4 level was significantly higher among those with a higher smoking intensity. Accordingly, the multivariate analysis identified a significant relationship between smoking status and serum IgG4 elevation.ConclusionIn this study, smoking was identified as a lifestyle factor correlating positively with elevated serum IgG4 levels.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124417/fullIgG4-related diseasehealth checkupIgG4magnetic bead panel assaysmoking |
| spellingShingle | Yoshika Tsuji Tomohiro Koga Tomohiro Koga Fumiaki Nonaka Kenichi Nobusue Shin-ya Kawashiri Hirotomo Yamanashi Takahiro Maeda Takahiro Maeda Kazuhiko Arima Kazuhiko Arima Kiyoshi Aoyagi Kiyoshi Aoyagi Meiko Takahashi Shuji Kawaguchi Fumihiko Matsuda Hiroshi Fujii Mitsuhiro Kawano Hiroyuki Nakamura Atsushi Kawakami Atsushi Kawakami Mami Tamai Mami Tamai Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study Frontiers in Immunology IgG4-related disease health checkup IgG4 magnetic bead panel assay smoking |
| title | Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study |
| title_full | Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study |
| title_fullStr | Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study |
| title_full_unstemmed | Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study |
| title_short | Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study |
| title_sort | identification of risk factors for elevated serum igg4 levels in subjects in a large scale health checkup cohort study |
| topic | IgG4-related disease health checkup IgG4 magnetic bead panel assay smoking |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124417/full |
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