Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China
Background: Diphtheria-tetanus-pertussis (DTP) vaccine has already been involved in national vaccination program for several decades in China. The immunity against these diseases in the people of all ages is not well investigated. Materials and methods: Serum samples were tested for IgG antibodies t...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-06-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1840253 |
| _version_ | 1827809522829230080 |
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| author | Dandan Liu Xiaoping Cheng Shi Wei Lin Yuan Changhui Chen Kaihu Yao |
| author_facet | Dandan Liu Xiaoping Cheng Shi Wei Lin Yuan Changhui Chen Kaihu Yao |
| author_sort | Dandan Liu |
| collection | DOAJ |
| description | Background: Diphtheria-tetanus-pertussis (DTP) vaccine has already been involved in national vaccination program for several decades in China. The immunity against these diseases in the people of all ages is not well investigated. Materials and methods: Serum samples were tested for IgG antibodies to diphtheria toxoid (DT), tetanus toxoid (TT) and pertussis toxin (PT) by using commercial ELISA kits. Results: A total of 666 sera of patients from 1 day to 89 years of age was collected from 2018 to 2019. The protective rates of diphtheria, tetanus and pertussis were 45.5%, 54.4% and 4.7%, respectively. Only 4.7% of the study population had seropositivity against three of the diseases. Young infant (<3 m) and adult (>18y) were generally lack of protective antibody against diphtheria (81.7% and 58.3%) and tetanus (91.5% and 86.2%). An obvious increase in immunity level of diphtheria and tetanus was observed at 3 m-3y, but there was no significant increase of immunity to pertussis at any age group. All age groups showed low immunity to pertussis. Conclusions: The present results revealed the susceptibility to diphtheria and tetanus in young infants and adults, and the susceptibility to pertussis over the ages, which highlight the need to improve the current vaccination program. |
| first_indexed | 2024-03-11T22:41:43Z |
| format | Article |
| id | doaj.art-4bfb88b6c00340dd9e688d657afc8ccf |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:41:43Z |
| publishDate | 2021-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-4bfb88b6c00340dd9e688d657afc8ccf2023-09-22T08:51:52ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-06-011761757176210.1080/21645515.2020.18402531840253Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland ChinaDandan Liu0Xiaoping Cheng1Shi Wei2Lin YuanChanghui Chen3Kaihu Yao4Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthYouyang County People’s HospitalBeijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthYouyang County People’s HospitalBeijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBackground: Diphtheria-tetanus-pertussis (DTP) vaccine has already been involved in national vaccination program for several decades in China. The immunity against these diseases in the people of all ages is not well investigated. Materials and methods: Serum samples were tested for IgG antibodies to diphtheria toxoid (DT), tetanus toxoid (TT) and pertussis toxin (PT) by using commercial ELISA kits. Results: A total of 666 sera of patients from 1 day to 89 years of age was collected from 2018 to 2019. The protective rates of diphtheria, tetanus and pertussis were 45.5%, 54.4% and 4.7%, respectively. Only 4.7% of the study population had seropositivity against three of the diseases. Young infant (<3 m) and adult (>18y) were generally lack of protective antibody against diphtheria (81.7% and 58.3%) and tetanus (91.5% and 86.2%). An obvious increase in immunity level of diphtheria and tetanus was observed at 3 m-3y, but there was no significant increase of immunity to pertussis at any age group. All age groups showed low immunity to pertussis. Conclusions: The present results revealed the susceptibility to diphtheria and tetanus in young infants and adults, and the susceptibility to pertussis over the ages, which highlight the need to improve the current vaccination program.http://dx.doi.org/10.1080/21645515.2020.1840253pertussisdiphtheriatetanusseroprevalencevaccination |
| spellingShingle | Dandan Liu Xiaoping Cheng Shi Wei Lin Yuan Changhui Chen Kaihu Yao Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China Human Vaccines & Immunotherapeutics pertussis diphtheria tetanus seroprevalence vaccination |
| title | Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China |
| title_full | Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China |
| title_fullStr | Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China |
| title_full_unstemmed | Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China |
| title_short | Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China |
| title_sort | decline of serologic immunity to diphtheria tetanus and pertussis with age suggested a full life vaccination in mainland china |
| topic | pertussis diphtheria tetanus seroprevalence vaccination |
| url | http://dx.doi.org/10.1080/21645515.2020.1840253 |
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