Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs:...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4747465?pdf=render |
| _version_ | 1811259846882754560 |
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| author | Hirotsugu Hatai Alice Lepelley Wangyong Zeng Matthew S Hayden Sankar Ghosh |
| author_facet | Hirotsugu Hatai Alice Lepelley Wangyong Zeng Matthew S Hayden Sankar Ghosh |
| author_sort | Hirotsugu Hatai |
| collection | DOAJ |
| description | Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs: Salmonella and E. coli flagellin FliC and Toxoplasma gondii profilin-like protein. Given the highly divergent biology of these pathogens recognized by TLR11, it is unclear whether common mechanisms are used to recognize these distinct protein PAMPs. Here we show that TLR11 interacts with these two PAMPs using different receptor domains. Furthermore, TLR11 binding to flagellin and profilin exhibits differential dependency on pH and receptor ectodomain cleavage. |
| first_indexed | 2024-04-12T18:37:48Z |
| format | Article |
| id | doaj.art-4bfbb5f151354d81a7c2d424e245eca8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T18:37:48Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4bfbb5f151354d81a7c2d424e245eca82022-12-22T03:20:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014898710.1371/journal.pone.0148987Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.Hirotsugu HataiAlice LepelleyWangyong ZengMatthew S HaydenSankar GhoshToll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs: Salmonella and E. coli flagellin FliC and Toxoplasma gondii profilin-like protein. Given the highly divergent biology of these pathogens recognized by TLR11, it is unclear whether common mechanisms are used to recognize these distinct protein PAMPs. Here we show that TLR11 interacts with these two PAMPs using different receptor domains. Furthermore, TLR11 binding to flagellin and profilin exhibits differential dependency on pH and receptor ectodomain cleavage.http://europepmc.org/articles/PMC4747465?pdf=render |
| spellingShingle | Hirotsugu Hatai Alice Lepelley Wangyong Zeng Matthew S Hayden Sankar Ghosh Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms. PLoS ONE |
| title | Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms. |
| title_full | Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms. |
| title_fullStr | Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms. |
| title_full_unstemmed | Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms. |
| title_short | Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms. |
| title_sort | toll like receptor 11 tlr11 interacts with flagellin and profilin through disparate mechanisms |
| url | http://europepmc.org/articles/PMC4747465?pdf=render |
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