Colorectal Cancer and Probiotics: Are Bugs Really Drugs?
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient to the disease such as age, family history, ethnicity, and lifestyle. There are different genetic factors and diseases that also increase a person’s risk for developing CRC....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/5/1162 |
| _version_ | 1797568737768898560 |
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| author | Purushottam Lamichhane Morgan Maiolini Omar Alnafoosi Sedra Hussein Hasan Alnafoosi Stewart Umbela Tayanna Richardson Nevien Alla Narottam Lamichhane Bobban Subhadra Rahul R. Deshmukh |
| author_facet | Purushottam Lamichhane Morgan Maiolini Omar Alnafoosi Sedra Hussein Hasan Alnafoosi Stewart Umbela Tayanna Richardson Nevien Alla Narottam Lamichhane Bobban Subhadra Rahul R. Deshmukh |
| author_sort | Purushottam Lamichhane |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient to the disease such as age, family history, ethnicity, and lifestyle. There are different genetic factors and diseases that also increase a person’s risk for developing CRC. Studies have found associations between gut microbiome and the risk for developing versus protection against CRC. Normal gut microbiome aid in daily functions of the human body such as absorption, metabolism, detoxification, and regulation of inflammation. While some species of bacteria prevent CRC development and aid in therapeutic responses to various treatment regiments, other species seem to promote CRC pathogenesis. In this regard, many studies have been conducted to not only understand the biology behind these opposing different bacterial species; but also to determine if supplementation of these tumor opposing bacterial species as probiotics lends toward decreased risk of CRC development and improved therapeutic responses in patients with CRC. In this literature review, we aim to discuss the basics on colorectal cancer (epidemiology, risk factors, targets, treatments), discuss associations between different bacterial strains and CRC, and discuss probiotics and their roles in CRC prevention and treatment. |
| first_indexed | 2024-03-10T20:01:12Z |
| format | Article |
| id | doaj.art-4bfdf2945dcf400aaec30d213eb9c54a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:01:12Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4bfdf2945dcf400aaec30d213eb9c54a2023-11-19T23:31:28ZengMDPI AGCancers2072-66942020-05-01125116210.3390/cancers12051162Colorectal Cancer and Probiotics: Are Bugs Really Drugs?Purushottam Lamichhane0Morgan Maiolini1Omar Alnafoosi2Sedra Hussein3Hasan Alnafoosi4Stewart Umbela5Tayanna Richardson6Nevien Alla7Narottam Lamichhane8Bobban Subhadra9Rahul R. Deshmukh10LECOM School of Dental Medicine, 4800 Lakewood Ranch Blvd, Bradenton, FL 34211, USALECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USALECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USAUpstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USALECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USALECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USALECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USALECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USADepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USABIOM Pharmaceuticals, 2203 Industrial Blvd, Sarasota, FL 34234, USALECOM School of Pharmacy, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USAColorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient to the disease such as age, family history, ethnicity, and lifestyle. There are different genetic factors and diseases that also increase a person’s risk for developing CRC. Studies have found associations between gut microbiome and the risk for developing versus protection against CRC. Normal gut microbiome aid in daily functions of the human body such as absorption, metabolism, detoxification, and regulation of inflammation. While some species of bacteria prevent CRC development and aid in therapeutic responses to various treatment regiments, other species seem to promote CRC pathogenesis. In this regard, many studies have been conducted to not only understand the biology behind these opposing different bacterial species; but also to determine if supplementation of these tumor opposing bacterial species as probiotics lends toward decreased risk of CRC development and improved therapeutic responses in patients with CRC. In this literature review, we aim to discuss the basics on colorectal cancer (epidemiology, risk factors, targets, treatments), discuss associations between different bacterial strains and CRC, and discuss probiotics and their roles in CRC prevention and treatment.https://www.mdpi.com/2072-6694/12/5/1162colorectal cancerchemopreventionprobioticsgut microflorabacteria |
| spellingShingle | Purushottam Lamichhane Morgan Maiolini Omar Alnafoosi Sedra Hussein Hasan Alnafoosi Stewart Umbela Tayanna Richardson Nevien Alla Narottam Lamichhane Bobban Subhadra Rahul R. Deshmukh Colorectal Cancer and Probiotics: Are Bugs Really Drugs? Cancers colorectal cancer chemoprevention probiotics gut microflora bacteria |
| title | Colorectal Cancer and Probiotics: Are Bugs Really Drugs? |
| title_full | Colorectal Cancer and Probiotics: Are Bugs Really Drugs? |
| title_fullStr | Colorectal Cancer and Probiotics: Are Bugs Really Drugs? |
| title_full_unstemmed | Colorectal Cancer and Probiotics: Are Bugs Really Drugs? |
| title_short | Colorectal Cancer and Probiotics: Are Bugs Really Drugs? |
| title_sort | colorectal cancer and probiotics are bugs really drugs |
| topic | colorectal cancer chemoprevention probiotics gut microflora bacteria |
| url | https://www.mdpi.com/2072-6694/12/5/1162 |
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