Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-06-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916300348 |
| _version_ | 1828775048535605248 |
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| author | Thomas Lanyon-Hogg Naoko Masumoto George Bodakh Antonio D. Konitsiotis Emmanuelle Thinon Ursula R. Rodgers Raymond J. Owens Anthony I. Magee Edward W. Tate |
| author_facet | Thomas Lanyon-Hogg Naoko Masumoto George Bodakh Antonio D. Konitsiotis Emmanuelle Thinon Ursula R. Rodgers Raymond J. Owens Anthony I. Magee Edward W. Tate |
| author_sort | Thomas Lanyon-Hogg |
| collection | DOAJ |
| description | In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. Keywords: Synthesis, Inhibitors, Hedgehog acyltransferase, Conformation |
| first_indexed | 2024-12-11T15:33:18Z |
| format | Article |
| id | doaj.art-4bfe980dcf9a43e8805f3661c29e6981 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T15:33:18Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-4bfe980dcf9a43e8805f3661c29e69812022-12-22T01:00:00ZengElsevierData in Brief2352-34092016-06-017257281Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferaseThomas Lanyon-Hogg0Naoko Masumoto1George Bodakh2Antonio D. Konitsiotis3Emmanuelle Thinon4Ursula R. Rodgers5Raymond J. Owens6Anthony I. Magee7Edward W. Tate8Department of Chemistry, Imperial College London, SW7 2AZ, UK; Institute of Chemical Biology, Imperial College London, SW72AZ, UKDepartment of Chemistry, Imperial College London, SW7 2AZ, UK; Institute of Chemical Biology, Imperial College London, SW72AZ, UKDepartment of Chemistry, Imperial College London, SW7 2AZ, UK; Institute of Chemical Biology, Imperial College London, SW72AZ, UKMolecular Medicine Section, National Heart & Lung Institute, Imperial College London, London SW7 2AZ, UKDepartment of Chemistry, Imperial College London, SW7 2AZ, UK; Institute of Chemical Biology, Imperial College London, SW72AZ, UKMolecular Medicine Section, National Heart & Lung Institute, Imperial College London, London SW7 2AZ, UKOxford Protein Production Facility UK, The Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Science & Innovation Centre, Harwell OX11 0FA, UKMolecular Medicine Section, National Heart & Lung Institute, Imperial College London, London SW7 2AZ, UK; Corresponding author at: Molecular Medicine Section, National Heart & Lung Institute, Imperial College London, London SW7 2AZ, UK. Tel.: +44 20 7594 3135.Department of Chemistry, Imperial College London, SW7 2AZ, UK; Institute of Chemical Biology, Imperial College London, SW72AZ, UK; Corresponding author at: Institute of Chemical Biology, Department of Chemistry, Imperial College London, London SW7 2AZ, UK. Tel.: +44 20 7594 3752.In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. Keywords: Synthesis, Inhibitors, Hedgehog acyltransferase, Conformationhttp://www.sciencedirect.com/science/article/pii/S2352340916300348 |
| spellingShingle | Thomas Lanyon-Hogg Naoko Masumoto George Bodakh Antonio D. Konitsiotis Emmanuelle Thinon Ursula R. Rodgers Raymond J. Owens Anthony I. Magee Edward W. Tate Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase Data in Brief |
| title | Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase |
| title_full | Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase |
| title_fullStr | Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase |
| title_full_unstemmed | Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase |
| title_short | Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase |
| title_sort | synthesis and characterisation of 5 acyl 6 7 dihydrothieno 3 2 c pyridine inhibitors of hedgehog acyltransferase |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916300348 |
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