Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder
Objective: Our aim is to define the extent of comorbidities in order to improve clinical care of patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) utilizing the REM Sleep Behavior Disorder Associations with Parkinson's Disease Study (RAPiDS) cohort. Methods: Consecutive...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Clinical Parkinsonism & Related Disorders |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590112520300128 |
| _version_ | 1818323799333928960 |
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| author | Daniel A. Barone Fei Wang Lisa Ravdin Mary Vo Andrea Lee Harini Sarva Natalie Hellmers Ana C. Krieger Claire Henchcliffe |
| author_facet | Daniel A. Barone Fei Wang Lisa Ravdin Mary Vo Andrea Lee Harini Sarva Natalie Hellmers Ana C. Krieger Claire Henchcliffe |
| author_sort | Daniel A. Barone |
| collection | DOAJ |
| description | Objective: Our aim is to define the extent of comorbidities in order to improve clinical care of patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) utilizing the REM Sleep Behavior Disorder Associations with Parkinson's Disease Study (RAPiDS) cohort. Methods: Consecutive adult study participants with iRBD confirmed on polysomnogram (PSG) were prospectively recruited from the Weill Cornell Center for Sleep Medicine. Evaluations comprised multiple facets of sleep, neurological, autonomic, and psychiatric function. Results: Participants evaluated included 30 individuals with iRBD, with mean 1.5 ± 2.3 years from PSG to neuropsychiatric evaluation. Mean age was 59.5 ± 16.0 years at time of PSG, and 6/30 were women. Urinary difficulties were reported in 14/30 (47%): slight 7 (23%), mild 4 (13%), moderate 2 (7%), and severe 1 (3.0%). Ten out of 29 (34%) had abnormal Montreal Cognitive Assessment (MoCA) scores and the mean was 26.5 ± 3.2. The distribution of MoCA scores was significantly associated with urinary problems insofar as the more severe urinary problems were, the lower the MoCA scores (p = 0.04). Conclusions: In this RAPiDS cohort, we detected an unexpectedly high occurrence of non-motor dysfunction. Our results point to the need for screening patients with iRBD for complaints that are actionable, for example those affecting mood, cognition, urinary function, and bowel function. We propose the term RBD+ to be used to identify such individuals. For the quality of life in patients diagnosed with RBD, a closer look by the clinician should be enacted, with appropriate referrals and workup. |
| first_indexed | 2024-12-13T11:18:26Z |
| format | Article |
| id | doaj.art-4bff1d0e01b24a3aa968a7cf8d1ace5f |
| institution | Directory Open Access Journal |
| issn | 2590-1125 |
| language | English |
| last_indexed | 2024-12-13T11:18:26Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Parkinsonism & Related Disorders |
| spelling | doaj.art-4bff1d0e01b24a3aa968a7cf8d1ace5f2022-12-21T23:48:33ZengElsevierClinical Parkinsonism & Related Disorders2590-11252020-01-013100044Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorderDaniel A. Barone0Fei Wang1Lisa Ravdin2Mary Vo3Andrea Lee4Harini Sarva5Natalie Hellmers6Ana C. Krieger7Claire Henchcliffe8Corresponding author at: Weill Cornell Medical College, Center for Sleep Medicine, 425 East 61st 5th Floor, New York, NY 10065, United States of America.; Weill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaWeill Cornell Medical College, New York, NY, United States of AmericaObjective: Our aim is to define the extent of comorbidities in order to improve clinical care of patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) utilizing the REM Sleep Behavior Disorder Associations with Parkinson's Disease Study (RAPiDS) cohort. Methods: Consecutive adult study participants with iRBD confirmed on polysomnogram (PSG) were prospectively recruited from the Weill Cornell Center for Sleep Medicine. Evaluations comprised multiple facets of sleep, neurological, autonomic, and psychiatric function. Results: Participants evaluated included 30 individuals with iRBD, with mean 1.5 ± 2.3 years from PSG to neuropsychiatric evaluation. Mean age was 59.5 ± 16.0 years at time of PSG, and 6/30 were women. Urinary difficulties were reported in 14/30 (47%): slight 7 (23%), mild 4 (13%), moderate 2 (7%), and severe 1 (3.0%). Ten out of 29 (34%) had abnormal Montreal Cognitive Assessment (MoCA) scores and the mean was 26.5 ± 3.2. The distribution of MoCA scores was significantly associated with urinary problems insofar as the more severe urinary problems were, the lower the MoCA scores (p = 0.04). Conclusions: In this RAPiDS cohort, we detected an unexpectedly high occurrence of non-motor dysfunction. Our results point to the need for screening patients with iRBD for complaints that are actionable, for example those affecting mood, cognition, urinary function, and bowel function. We propose the term RBD+ to be used to identify such individuals. For the quality of life in patients diagnosed with RBD, a closer look by the clinician should be enacted, with appropriate referrals and workup.http://www.sciencedirect.com/science/article/pii/S2590112520300128RBDREM sleepAlpha-synucleinopathyParkinson's disease |
| spellingShingle | Daniel A. Barone Fei Wang Lisa Ravdin Mary Vo Andrea Lee Harini Sarva Natalie Hellmers Ana C. Krieger Claire Henchcliffe Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder Clinical Parkinsonism & Related Disorders RBD REM sleep Alpha-synucleinopathy Parkinson's disease |
| title | Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder |
| title_full | Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder |
| title_fullStr | Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder |
| title_full_unstemmed | Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder |
| title_short | Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder |
| title_sort | comorbid neuropsychiatric and autonomic features in rem sleep behavior disorder |
| topic | RBD REM sleep Alpha-synucleinopathy Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2590112520300128 |
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