Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthma
Abstract Background The aim of this study is to reveal whether basic salivary proline‐rich protein BstNI subfamily 1 (PRB1) may be used as a diagnostic biomarker for type 2‐high asthma. Methods PRB1 protein levels in the induced sputum of 67 subjects with asthma and 27 controls were determined by an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.602 |
| _version_ | 1818775201099284480 |
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| author | Fengjia Chen Yuxia Liang Zhimin Zeng Lijuan Du Changyi Xu Yubiao Guo Canmao Xie |
| author_facet | Fengjia Chen Yuxia Liang Zhimin Zeng Lijuan Du Changyi Xu Yubiao Guo Canmao Xie |
| author_sort | Fengjia Chen |
| collection | DOAJ |
| description | Abstract Background The aim of this study is to reveal whether basic salivary proline‐rich protein BstNI subfamily 1 (PRB1) may be used as a diagnostic biomarker for type 2‐high asthma. Methods PRB1 protein levels in the induced sputum of 67 subjects with asthma and 27 controls were determined by an enzyme‐linked immunosorbent assay. Correlation analyses between PRB1 in the induced sputum and airway inflammatory indicators were also performed. Results PRB1 protein levels were significantly upregulated in the induced sputum of asthmatic patients (p =0.0098) and correlated with clinical eosinophil‐related indicators and type 2 airway inflammation. These results indicate that PRB1 is a promising biomarker for type 2‐high asthma. Conclusions The expression of PRB1 in induced sputum is a potential biomarker for type 2‐high asthma. The results of this study present new insights into the diagnosis and treatment of asthma. |
| first_indexed | 2024-12-18T10:53:16Z |
| format | Article |
| id | doaj.art-4c013190882e4ce5a37f625dc1c67f49 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-12-18T10:53:16Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-4c013190882e4ce5a37f625dc1c67f492022-12-21T21:10:24ZengWileyImmunity, Inflammation and Disease2050-45272022-04-01104n/an/a10.1002/iid3.602Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthmaFengjia Chen0Yuxia Liang1Zhimin Zeng2Lijuan Du3Changyi Xu4Yubiao Guo5Canmao Xie6Division of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDivision of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDivision of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDivision of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDivision of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDivision of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDivision of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaAbstract Background The aim of this study is to reveal whether basic salivary proline‐rich protein BstNI subfamily 1 (PRB1) may be used as a diagnostic biomarker for type 2‐high asthma. Methods PRB1 protein levels in the induced sputum of 67 subjects with asthma and 27 controls were determined by an enzyme‐linked immunosorbent assay. Correlation analyses between PRB1 in the induced sputum and airway inflammatory indicators were also performed. Results PRB1 protein levels were significantly upregulated in the induced sputum of asthmatic patients (p =0.0098) and correlated with clinical eosinophil‐related indicators and type 2 airway inflammation. These results indicate that PRB1 is a promising biomarker for type 2‐high asthma. Conclusions The expression of PRB1 in induced sputum is a potential biomarker for type 2‐high asthma. The results of this study present new insights into the diagnosis and treatment of asthma.https://doi.org/10.1002/iid3.602asthmainduced sputumphenotypePRB1 |
| spellingShingle | Fengjia Chen Yuxia Liang Zhimin Zeng Lijuan Du Changyi Xu Yubiao Guo Canmao Xie Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthma Immunity, Inflammation and Disease asthma induced sputum phenotype PRB1 |
| title | Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthma |
| title_full | Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthma |
| title_fullStr | Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthma |
| title_full_unstemmed | Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthma |
| title_short | Association of increased basic salivary proline‐rich protein 1 levels in induced sputum with type 2‐high asthma |
| title_sort | association of increased basic salivary proline rich protein 1 levels in induced sputum with type 2 high asthma |
| topic | asthma induced sputum phenotype PRB1 |
| url | https://doi.org/10.1002/iid3.602 |
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