F-spondin Is Essential for Maintaining Circadian Rhythms
The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian behaviors. SCN neurons have intrinsic, self-sustained rhythmicity that is governed by transcription-translation feedback loops. Intrinsic rhythms within the SCN do not match the day-night cycle and are therefore entraine...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-02-01
|
| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fncir.2018.00013/full |
| _version_ | 1819243627988123648 |
|---|---|
| author | Gabriela L. Carrillo Gabriela L. Carrillo Jianmin Su Aboozar Monavarfeshani Aboozar Monavarfeshani Michael A. Fox Michael A. Fox Michael A. Fox |
| author_facet | Gabriela L. Carrillo Gabriela L. Carrillo Jianmin Su Aboozar Monavarfeshani Aboozar Monavarfeshani Michael A. Fox Michael A. Fox Michael A. Fox |
| author_sort | Gabriela L. Carrillo |
| collection | DOAJ |
| description | The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian behaviors. SCN neurons have intrinsic, self-sustained rhythmicity that is governed by transcription-translation feedback loops. Intrinsic rhythms within the SCN do not match the day-night cycle and are therefore entrained by light-derived cues. Such cues are transmitted to the SCN by a class of intrinsically photosensitive retinal ganglion cells (ipRGCs). In the present study, we sought to identify how axons from ipRGCs target the SCN. While none of the potential targeting cues identified appeared necessary for retinohypothalamic innervation, we unexpectedly identified a novel role for the extracellular matrix protein F-spondin in circadian behavior. In the absence of F-spondin, mice lost their ability to maintain typical intrinsic rhythmicity. Moreover, F-spondin loss results in the displacement of vasoactive intestinal peptide (VIP)-expressing neurons, a class of neurons that are essential for maintaining rhythmicity among SCN neurons. Thus, this study highlights a novel role for F-spondin in maintaining circadian rhythms. |
| first_indexed | 2024-12-23T14:58:43Z |
| format | Article |
| id | doaj.art-4c07f9fd876a47bf86e1664e9e254e0e |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-23T14:58:43Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-4c07f9fd876a47bf86e1664e9e254e0e2022-12-21T17:42:41ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102018-02-011210.3389/fncir.2018.00013309189F-spondin Is Essential for Maintaining Circadian RhythmsGabriela L. Carrillo0Gabriela L. Carrillo1Jianmin Su2Aboozar Monavarfeshani3Aboozar Monavarfeshani4Michael A. Fox5Michael A. Fox6Michael A. Fox7Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, Roanoke, VA, United StatesGraduate Program in Translational Biology, Medicine and Health, Virginia Tech, Blacksburg, VA, United StatesDevelopmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, Roanoke, VA, United StatesDevelopmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, Roanoke, VA, United StatesDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United StatesDevelopmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, Roanoke, VA, United StatesDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United StatesDepartment of Pediatrics, Virginia Tech Carilion School of Medicine, Roanoke, VA, United StatesThe suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian behaviors. SCN neurons have intrinsic, self-sustained rhythmicity that is governed by transcription-translation feedback loops. Intrinsic rhythms within the SCN do not match the day-night cycle and are therefore entrained by light-derived cues. Such cues are transmitted to the SCN by a class of intrinsically photosensitive retinal ganglion cells (ipRGCs). In the present study, we sought to identify how axons from ipRGCs target the SCN. While none of the potential targeting cues identified appeared necessary for retinohypothalamic innervation, we unexpectedly identified a novel role for the extracellular matrix protein F-spondin in circadian behavior. In the absence of F-spondin, mice lost their ability to maintain typical intrinsic rhythmicity. Moreover, F-spondin loss results in the displacement of vasoactive intestinal peptide (VIP)-expressing neurons, a class of neurons that are essential for maintaining rhythmicity among SCN neurons. Thus, this study highlights a novel role for F-spondin in maintaining circadian rhythms.http://journal.frontiersin.org/article/10.3389/fncir.2018.00013/fullsuprachiasmatic nucleusextracellular matrixcircadian rhythmphotoentrainmentintrinsically photosensitive retinal ganglion cells |
| spellingShingle | Gabriela L. Carrillo Gabriela L. Carrillo Jianmin Su Aboozar Monavarfeshani Aboozar Monavarfeshani Michael A. Fox Michael A. Fox Michael A. Fox F-spondin Is Essential for Maintaining Circadian Rhythms Frontiers in Neural Circuits suprachiasmatic nucleus extracellular matrix circadian rhythm photoentrainment intrinsically photosensitive retinal ganglion cells |
| title | F-spondin Is Essential for Maintaining Circadian Rhythms |
| title_full | F-spondin Is Essential for Maintaining Circadian Rhythms |
| title_fullStr | F-spondin Is Essential for Maintaining Circadian Rhythms |
| title_full_unstemmed | F-spondin Is Essential for Maintaining Circadian Rhythms |
| title_short | F-spondin Is Essential for Maintaining Circadian Rhythms |
| title_sort | f spondin is essential for maintaining circadian rhythms |
| topic | suprachiasmatic nucleus extracellular matrix circadian rhythm photoentrainment intrinsically photosensitive retinal ganglion cells |
| url | http://journal.frontiersin.org/article/10.3389/fncir.2018.00013/full |
| work_keys_str_mv | AT gabrielalcarrillo fspondinisessentialformaintainingcircadianrhythms AT gabrielalcarrillo fspondinisessentialformaintainingcircadianrhythms AT jianminsu fspondinisessentialformaintainingcircadianrhythms AT aboozarmonavarfeshani fspondinisessentialformaintainingcircadianrhythms AT aboozarmonavarfeshani fspondinisessentialformaintainingcircadianrhythms AT michaelafox fspondinisessentialformaintainingcircadianrhythms AT michaelafox fspondinisessentialformaintainingcircadianrhythms AT michaelafox fspondinisessentialformaintainingcircadianrhythms |