ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer

ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer

ABSTRACTImmunosuppressive tumor microenvironment (TME) impedes anti-tumor immune responses and contributes to immunotherapy resistance in triple-negative breast cancer (TNBC). ADAM12, a member of cell surface metalloproteases, is selectively upregulated in mesenchymal/claudin-low TNBCs, where its ex...

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Bibliographic Details
Main Authors: Guanpeng Wang, Yeni Romero, Indhujah Thevarajan, Anna Zolkiewska
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Triple negative breast cancer
mouse models
ADAM
checkpoint inhibition
tumor-infiltrating immune cells
tumor microenvironment
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2158006

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