Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12394 |
| _version_ | 1797509987446030336 |
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| author | Yoshitaka Kimura Daisuke Tsukui Hajime Kono |
| author_facet | Yoshitaka Kimura Daisuke Tsukui Hajime Kono |
| author_sort | Yoshitaka Kimura |
| collection | DOAJ |
| description | Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive oxygen species (ROS) are produced simultaneously with the formation of uric acid by xanthine oxidases. Intracellular uric acid has also been reported to promote the production of ROS. The ROS and the intracellular uric acid itself regulate several intracellular signaling pathways, and alterations in these pathways may result in the development of atherosclerotic lesions. In this review, we describe the effect of uric acid on various molecular signals and the potential mechanisms of atherosclerosis development in hyperuricemia. Furthermore, we discuss the efficacy of treatments for hyperuricemia to protect against the development of atherosclerosis. |
| first_indexed | 2024-03-10T05:25:31Z |
| format | Article |
| id | doaj.art-4c0b5fcc8f7046d79c0b7b979afcfc51 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:25:31Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4c0b5fcc8f7046d79c0b7b979afcfc512023-11-22T23:41:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221239410.3390/ijms222212394Uric Acid in Inflammation and the Pathogenesis of AtherosclerosisYoshitaka Kimura0Daisuke Tsukui1Hajime Kono2Department of Internal Medicine, Faculty of Medicine, Teikyo University of Medicine, Tokyo 173-8605, JapanDepartment of Internal Medicine, Faculty of Medicine, Teikyo University of Medicine, Tokyo 173-8605, JapanDepartment of Internal Medicine, Faculty of Medicine, Teikyo University of Medicine, Tokyo 173-8605, JapanHyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive oxygen species (ROS) are produced simultaneously with the formation of uric acid by xanthine oxidases. Intracellular uric acid has also been reported to promote the production of ROS. The ROS and the intracellular uric acid itself regulate several intracellular signaling pathways, and alterations in these pathways may result in the development of atherosclerotic lesions. In this review, we describe the effect of uric acid on various molecular signals and the potential mechanisms of atherosclerosis development in hyperuricemia. Furthermore, we discuss the efficacy of treatments for hyperuricemia to protect against the development of atherosclerosis.https://www.mdpi.com/1422-0067/22/22/12394hyperuricemiaatherosclerosisinflammationreactive oxygen species |
| spellingShingle | Yoshitaka Kimura Daisuke Tsukui Hajime Kono Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis International Journal of Molecular Sciences hyperuricemia atherosclerosis inflammation reactive oxygen species |
| title | Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis |
| title_full | Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis |
| title_fullStr | Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis |
| title_full_unstemmed | Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis |
| title_short | Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis |
| title_sort | uric acid in inflammation and the pathogenesis of atherosclerosis |
| topic | hyperuricemia atherosclerosis inflammation reactive oxygen species |
| url | https://www.mdpi.com/1422-0067/22/22/12394 |
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