The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis
Over the last decade, a considerable amount of new data have revealed the beneficial effects of exercise on hippocampal neurogenesis and the maintenance or improvement of cognitive function. Investigations with animal models, as well as human studies, have yielded novel understanding of the mechanis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1202349/full |
| _version_ | 1797454825639641088 |
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| author | Robert R. Kraemer Bradley R. Kraemer |
| author_facet | Robert R. Kraemer Bradley R. Kraemer |
| author_sort | Robert R. Kraemer |
| collection | DOAJ |
| description | Over the last decade, a considerable amount of new data have revealed the beneficial effects of exercise on hippocampal neurogenesis and the maintenance or improvement of cognitive function. Investigations with animal models, as well as human studies, have yielded novel understanding of the mechanisms through which endocrine signaling can stimulate neurogenesis, as well as the effects of exercise on acute and/or chronic levels of these circulating hormones. Considering the effects of aging on the decline of specific endocrine factors that affect brain health, insights in this area of research are particularly important. In this review, we discuss how different forms of exercise influence the peripheral production of specific endocrine factors, with particular emphasis on brain-derived neurotrophic factor, growth hormone, insulin-like growth factor-1, ghrelin, estrogen, testosterone, irisin, vascular endothelial growth factor, erythropoietin, and cortisol. We also describe mechanisms through which these endocrine responses to exercise induce cellular changes that increase hippocampal neurogenesis and improve cognitive function. |
| first_indexed | 2024-03-09T15:43:42Z |
| format | Article |
| id | doaj.art-4c0b82601c0642bb8a2daaefa1278750 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T15:43:42Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4c0b82601c0642bb8a2daaefa12787502023-11-24T22:07:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-11-011410.3389/fendo.2023.12023491202349The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesisRobert R. Kraemer0Bradley R. Kraemer1Department of Kinesiology and Health Studies, Southeastern Louisiana University, Hammond, LA, United StatesDepartment of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, United StatesOver the last decade, a considerable amount of new data have revealed the beneficial effects of exercise on hippocampal neurogenesis and the maintenance or improvement of cognitive function. Investigations with animal models, as well as human studies, have yielded novel understanding of the mechanisms through which endocrine signaling can stimulate neurogenesis, as well as the effects of exercise on acute and/or chronic levels of these circulating hormones. Considering the effects of aging on the decline of specific endocrine factors that affect brain health, insights in this area of research are particularly important. In this review, we discuss how different forms of exercise influence the peripheral production of specific endocrine factors, with particular emphasis on brain-derived neurotrophic factor, growth hormone, insulin-like growth factor-1, ghrelin, estrogen, testosterone, irisin, vascular endothelial growth factor, erythropoietin, and cortisol. We also describe mechanisms through which these endocrine responses to exercise induce cellular changes that increase hippocampal neurogenesis and improve cognitive function.https://www.frontiersin.org/articles/10.3389/fendo.2023.1202349/fulltestosteroneinsulin-like growth factor (IGF- I)exerciseneurogenesisBrain-derived Neurotrophic Factor (BDNF)growth hormone |
| spellingShingle | Robert R. Kraemer Bradley R. Kraemer The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis Frontiers in Endocrinology testosterone insulin-like growth factor (IGF- I) exercise neurogenesis Brain-derived Neurotrophic Factor (BDNF) growth hormone |
| title | The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis |
| title_full | The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis |
| title_fullStr | The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis |
| title_full_unstemmed | The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis |
| title_short | The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis |
| title_sort | effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis |
| topic | testosterone insulin-like growth factor (IGF- I) exercise neurogenesis Brain-derived Neurotrophic Factor (BDNF) growth hormone |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1202349/full |
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