Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)
Objective: The purpose of this study was to identify patient characteristics and statin discontinuation-related factors in patients with hypercholesterolemia. Methods: A total of 532 patients (age mean+-SD: 57.4+-11.5 years; 52.4% women, 47.6% men) with hypercholesterolemia and statin discontinua...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KARE Publishing
2016-02-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-47041 |
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| author | Lale Tokgözoğlu Ramazan Özdemir Rojhat Altındağ Ceyhun Ceyhan Ekrem Yeter Cihan Öztürk Fahri Bayram Tuncay Delibaşı Muzaffer Değertekin Mustafa Hakan Dinçkal Ibrahim Keleş Ali Serdar Fak Sinan Aydogdu Cafer Zorkun Zeynep Tartan |
| author_facet | Lale Tokgözoğlu Ramazan Özdemir Rojhat Altındağ Ceyhun Ceyhan Ekrem Yeter Cihan Öztürk Fahri Bayram Tuncay Delibaşı Muzaffer Değertekin Mustafa Hakan Dinçkal Ibrahim Keleş Ali Serdar Fak Sinan Aydogdu Cafer Zorkun Zeynep Tartan |
| author_sort | Lale Tokgözoğlu |
| collection | DOAJ |
| description | Objective: The purpose of this study was to identify patient characteristics and statin discontinuation-related factors in patients with hypercholesterolemia.
Methods: A total of 532 patients (age mean+-SD: 57.4+-11.5 years; 52.4% women, 47.6% men) with hypercholesterolemia and statin discontinuation were included in this national cross-sectional noninterventional observational study. Data on socio-demographic characteristics of patients, cardiovascular risk factors, past treatment with and discontinuation of statin treatment were collected in one visit.
Results: Mean+-SD duration of hypercholesterolemia was 4.9+-4.2 years at time of discontinuation of statin treatment. Statin treatment was initiated by cardiologists in the majority of cases (55.8%), whereas discontinuation of statin treatment was decided by patients in the majority of cases (73.7%), with patients with higher (at least secondary education, 80.4%) more likely than those with lower (only primary education, 69.7%) to decide to discontinue treatment (p=0.022). Negative information about statin treatment disseminated by TV programs-mostly regarding coverage of hepatic (38.0%), renal (33.8%), and muscular (32.9%) side effects (32.9%)-was the most common reason for treatment discontinuation.
Conclusion: The decision to discontinue statin treatment was made at the patient's discretion in 74% of cases, with higher likelihood of patients with higher educational status deciding to discontinue treatment and switch to non-drug lipid-lowering alternatives. Cardiologists were the physicians most frequently responsible for the initiation of the statin treatment; coverage of several non-lifethreatening statin side effects by TV programs and patients' lack of information regarding high cholesterol and related risks were the leading factors predisposing to treatment discontinuation. |
| first_indexed | 2024-04-10T13:20:07Z |
| format | Article |
| id | doaj.art-4c0c0d49cde74c8d987d69ad70d054e2 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T13:20:07Z |
| publishDate | 2016-02-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-4c0c0d49cde74c8d987d69ad70d054e22023-02-15T16:12:05ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692016-02-01441536410.5543/tkda.2015.47041TKDA-47041Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)Lale Tokgözoğlu0Ramazan Özdemir1Rojhat Altındağ2Ceyhun Ceyhan3Ekrem Yeter4Cihan Öztürk5Fahri Bayram6Tuncay Delibaşı7Muzaffer Değertekin8Mustafa Hakan Dinçkal9Ibrahim Keleş10Ali Serdar Fak11Sinan Aydogdu12Cafer Zorkun13Zeynep Tartan14Department of Cardiology, Hacettepe University, Faculty of Medicine, Ankara, TurkeyDepartment of Cardiology, Inonu University, Faculty of Medicine, Malatya, TurkeyDepartment of Cardiology, Diyarbakir Training and Research Hospital, Diyarbakir, TurkeyDepartment of Cardiology, Adnan Menderes University, Faculty of Medicine, Aydin, TurkeyDepartment of Cardiology, Diskapi Yildirim Bayezit Research and Training Hospital, Ankara, TurkeyDepartment of Cardiology, Kahramanmaraş Pazarcık Private Middle East Health Center, Kahramanmaras, TurkeyDepartment Of Endocrinology And Metabolism, Erciyes University, Faculty of Medicine, Kayseri, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Yildirim Bayezit Research and Training Hospital, Ankara, TurkeyDepartment of Cardiology, Yeditepe University, Faculty of Medicine, Istanbul, TurkeyDepartment of Cardiology, Bagcilar Research and Training Hospital, Istanbul, TurkeyDepartment of Cardiology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, TurkeyDepartment of Cardiology, Akademi Hospital, Istanbul, TurkeyDepartment of Cardiology, Akademi Hospital, Istanbul, TurkeyDepartment of Cardiology, Akademi Hospital, Istanbul, TurkeyDepartment of Cardiology, Akademi Hospital, Istanbul, TurkeyObjective: The purpose of this study was to identify patient characteristics and statin discontinuation-related factors in patients with hypercholesterolemia. Methods: A total of 532 patients (age mean+-SD: 57.4+-11.5 years; 52.4% women, 47.6% men) with hypercholesterolemia and statin discontinuation were included in this national cross-sectional noninterventional observational study. Data on socio-demographic characteristics of patients, cardiovascular risk factors, past treatment with and discontinuation of statin treatment were collected in one visit. Results: Mean+-SD duration of hypercholesterolemia was 4.9+-4.2 years at time of discontinuation of statin treatment. Statin treatment was initiated by cardiologists in the majority of cases (55.8%), whereas discontinuation of statin treatment was decided by patients in the majority of cases (73.7%), with patients with higher (at least secondary education, 80.4%) more likely than those with lower (only primary education, 69.7%) to decide to discontinue treatment (p=0.022). Negative information about statin treatment disseminated by TV programs-mostly regarding coverage of hepatic (38.0%), renal (33.8%), and muscular (32.9%) side effects (32.9%)-was the most common reason for treatment discontinuation. Conclusion: The decision to discontinue statin treatment was made at the patient's discretion in 74% of cases, with higher likelihood of patients with higher educational status deciding to discontinue treatment and switch to non-drug lipid-lowering alternatives. Cardiologists were the physicians most frequently responsible for the initiation of the statin treatment; coverage of several non-lifethreatening statin side effects by TV programs and patients' lack of information regarding high cholesterol and related risks were the leading factors predisposing to treatment discontinuation.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-47041hypercholesterolemiapatient characteristics; predisposing factors; statin discontinuation; turkey |
| spellingShingle | Lale Tokgözoğlu Ramazan Özdemir Rojhat Altındağ Ceyhun Ceyhan Ekrem Yeter Cihan Öztürk Fahri Bayram Tuncay Delibaşı Muzaffer Değertekin Mustafa Hakan Dinçkal Ibrahim Keleş Ali Serdar Fak Sinan Aydogdu Cafer Zorkun Zeynep Tartan Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study) Türk Kardiyoloji Derneği Arşivi hypercholesterolemia patient characteristics; predisposing factors; statin discontinuation; turkey |
| title | Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study) |
| title_full | Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study) |
| title_fullStr | Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study) |
| title_full_unstemmed | Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study) |
| title_short | Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study) |
| title_sort | patient characteristics and statin discontinuation related factors during treatment of hypercholesterolemia an observational non interventional study in patients with statin discontinuation stay study |
| topic | hypercholesterolemia patient characteristics; predisposing factors; statin discontinuation; turkey |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-47041 |
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