Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the...
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MDPI AG
2021-09-01
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| Online Access: | https://www.mdpi.com/2072-6643/13/9/3197 |
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| author | Nina Wittorff Jensen Kim Katrine Bjerring Clemmensen Marie Møller Jensen Hanne Pedersen Kristine Færch Lars Jorge Diaz Jonas Salling Quist Joachim Størling |
| author_facet | Nina Wittorff Jensen Kim Katrine Bjerring Clemmensen Marie Møller Jensen Hanne Pedersen Kristine Færch Lars Jorge Diaz Jonas Salling Quist Joachim Størling |
| author_sort | Nina Wittorff Jensen |
| collection | DOAJ |
| description | Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all <i>p</i> < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake. |
| first_indexed | 2024-03-10T07:20:10Z |
| format | Article |
| id | doaj.art-4c0d12a17fc6484e95c017a7631ddbc1 |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:20:10Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4c0d12a17fc6484e95c017a7631ddbc12023-11-22T14:38:55ZengMDPI AGNutrients2072-66432021-09-01139319710.3390/nu13093197Associations between Postprandial Gut Hormones and Markers of Bone RemodelingNina Wittorff Jensen0Kim Katrine Bjerring Clemmensen1Marie Møller Jensen2Hanne Pedersen3Kristine Færch4Lars Jorge Diaz5Jonas Salling Quist6Joachim Størling7Clinical Prevention Research, Steno Diabetes Center Copenhagen, 2820 Gentofte, DenmarkClinical Prevention Research, Steno Diabetes Center Copenhagen, 2820 Gentofte, DenmarkClinical Prevention Research, Steno Diabetes Center Copenhagen, 2820 Gentofte, DenmarkClinical Prevention Research, Steno Diabetes Center Copenhagen, 2820 Gentofte, DenmarkClinical Prevention Research, Steno Diabetes Center Copenhagen, 2820 Gentofte, DenmarkClinical Epidemiology Research, Steno Diabetes Center Copenhagen, 2820 Gentofte, DenmarkClinical Prevention Research, Steno Diabetes Center Copenhagen, 2820 Gentofte, DenmarkDepartment of Biomedical Sciences, University of Copenhagen, 1165 Copenhagen, DenmarkGut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all <i>p</i> < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.https://www.mdpi.com/2072-6643/13/9/3197bone markersgut hormonesbone metabolismCTXP1NP |
| spellingShingle | Nina Wittorff Jensen Kim Katrine Bjerring Clemmensen Marie Møller Jensen Hanne Pedersen Kristine Færch Lars Jorge Diaz Jonas Salling Quist Joachim Størling Associations between Postprandial Gut Hormones and Markers of Bone Remodeling Nutrients bone markers gut hormones bone metabolism CTX P1NP |
| title | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
| title_full | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
| title_fullStr | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
| title_full_unstemmed | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
| title_short | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
| title_sort | associations between postprandial gut hormones and markers of bone remodeling |
| topic | bone markers gut hormones bone metabolism CTX P1NP |
| url | https://www.mdpi.com/2072-6643/13/9/3197 |
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