The Effect of NNK, A Tobacco Smoke Carcinogen, on the miRNA and Mismatch DNA Repair Expression Profiles in Lung and Head and Neck Squamous Cancer Cells

The Effect of NNK, A Tobacco Smoke Carcinogen, on the miRNA and Mismatch DNA Repair Expression Profiles in Lung and Head and Neck Squamous Cancer Cells

Tobacco smoking is a common risk factor for lung cancer and head and neck cancer. Molecular changes such as deregulation of miRNA expression have been linked to tobacco smoking in both types of cancer. Dysfunction of the Mismatch DNA repair (MMR) mechanism has also been associated with a poor progno...

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Bibliographic Details
Main Authors: Sotirios G. Doukas, Dimitra P. Vageli, George Lazopoulos, Demetrios A. Spandidos, Clarence T. Sasaki, Aristidis Tsatsakis
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
tobacco smoke
NNK
head and neck cancer
lung cancer
Mismatch DNA repair
MSH2
Online Access:https://www.mdpi.com/2073-4409/9/4/1031

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