Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture
Abstract Circulating adiponectin shows some relationships with the occurrence of cardiometabolic diseases and osteoporotic fracture, but little is known about their causal associations. This two-sample Mendelian randomization (MR) study aims to explore the causal roles of circulating adiponectin in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10586-1 |
| _version_ | 1817988648092565504 |
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| author | Muzi Zhang Xiaojun Chen Yong Zhu Lifeng Yin Zhengxue Quan Yunsheng Ou Bin He |
| author_facet | Muzi Zhang Xiaojun Chen Yong Zhu Lifeng Yin Zhengxue Quan Yunsheng Ou Bin He |
| author_sort | Muzi Zhang |
| collection | DOAJ |
| description | Abstract Circulating adiponectin shows some relationships with the occurrence of cardiometabolic diseases and osteoporotic fracture, but little is known about their causal associations. This two-sample Mendelian randomization (MR) study aims to explore the causal roles of circulating adiponectin in cardiometabolic diseases and osteoporotic fracture. We used 15 single nucleotide polymorphisms associated with circulating adiponectin as the instrumental variables. Inverse variance weighted, weighted median and MR-Egger regression methods were applied to study the causal associations. The results found that high circulating adiponectin was causally associated with reduced risk of type 2 diabetes (beta-estimate: −0.030, 95% CI: −0.048 to −0.011, SE: 0.009, P-value = 0.002) and may be the risk factor of coronary artery disease (beta-estimate: 0.012, 95% CI: 0.001 to 0.023, SE: 0.006, P-value = 0.030). No causal associations were seen between circulating adiponectin and other outcomes including heart failure, atrial fibrillation, cerebral ischemia, intracerebral hemorrhage or osteoporotic fracture. This study found the potential causal roles of high circulating adiponectin in reduced risk of type 2 diabetes and increased risk of coronary artery disease, which may help prevent and treat these two diseases. |
| first_indexed | 2024-04-14T00:37:38Z |
| format | Article |
| id | doaj.art-4c0d4af502ff419ca7dbae37b07dfbb0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-14T00:37:38Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4c0d4af502ff419ca7dbae37b07dfbb02022-12-22T02:22:19ZengNature PortfolioScientific Reports2045-23222022-04-011211910.1038/s41598-022-10586-1Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fractureMuzi Zhang0Xiaojun Chen1Yong Zhu2Lifeng Yin3Zhengxue Quan4Yunsheng Ou5Bin He6Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Circulating adiponectin shows some relationships with the occurrence of cardiometabolic diseases and osteoporotic fracture, but little is known about their causal associations. This two-sample Mendelian randomization (MR) study aims to explore the causal roles of circulating adiponectin in cardiometabolic diseases and osteoporotic fracture. We used 15 single nucleotide polymorphisms associated with circulating adiponectin as the instrumental variables. Inverse variance weighted, weighted median and MR-Egger regression methods were applied to study the causal associations. The results found that high circulating adiponectin was causally associated with reduced risk of type 2 diabetes (beta-estimate: −0.030, 95% CI: −0.048 to −0.011, SE: 0.009, P-value = 0.002) and may be the risk factor of coronary artery disease (beta-estimate: 0.012, 95% CI: 0.001 to 0.023, SE: 0.006, P-value = 0.030). No causal associations were seen between circulating adiponectin and other outcomes including heart failure, atrial fibrillation, cerebral ischemia, intracerebral hemorrhage or osteoporotic fracture. This study found the potential causal roles of high circulating adiponectin in reduced risk of type 2 diabetes and increased risk of coronary artery disease, which may help prevent and treat these two diseases.https://doi.org/10.1038/s41598-022-10586-1 |
| spellingShingle | Muzi Zhang Xiaojun Chen Yong Zhu Lifeng Yin Zhengxue Quan Yunsheng Ou Bin He Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture Scientific Reports |
| title | Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture |
| title_full | Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture |
| title_fullStr | Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture |
| title_full_unstemmed | Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture |
| title_short | Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture |
| title_sort | causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture |
| url | https://doi.org/10.1038/s41598-022-10586-1 |
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