Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms
Zinc, an essential micronutrient in the human body, is a component in over 300 enzymes and participates in regulating enzymatic activity. Zinc metalloenzymes play a crucial role in physiological processes including antioxidant, anti-inflammatory, and immune responses, as well as apoptosis. Aberrant...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/12/4456 |
| _version_ | 1797501769083781120 |
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| author | Yunqi Cheng Hongping Chen |
| author_facet | Yunqi Cheng Hongping Chen |
| author_sort | Yunqi Cheng |
| collection | DOAJ |
| description | Zinc, an essential micronutrient in the human body, is a component in over 300 enzymes and participates in regulating enzymatic activity. Zinc metalloenzymes play a crucial role in physiological processes including antioxidant, anti-inflammatory, and immune responses, as well as apoptosis. Aberrant enzyme activity can lead to various human diseases. In this review, we summarize zinc homeostasis, the roles of zinc in zinc metalloenzymes, the physiological processes of zinc metalloenzymes, and aberrant zinc metalloenzymes in human diseases. In addition, potential mechanisms of action are also discussed. This comprehensive understanding of the mechanisms of action of the regulatory functions of zinc in enzyme activity could inform novel zinc-micronutrient-supply strategies for the treatment of diseases. |
| first_indexed | 2024-03-10T03:23:18Z |
| format | Article |
| id | doaj.art-4c0e818b0fe6494eb54ddf65e9aea73d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:23:18Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4c0e818b0fe6494eb54ddf65e9aea73d2023-11-23T09:57:55ZengMDPI AGNutrients2072-66432021-12-011312445610.3390/nu13124456Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential MechanismsYunqi Cheng0Hongping Chen1Queen Mary School, Medical College, Nanchang University, Nanchang 330006, ChinaDepartment of Histology and Embryology, Medical College, Nanchang University, Nanchang 330006, ChinaZinc, an essential micronutrient in the human body, is a component in over 300 enzymes and participates in regulating enzymatic activity. Zinc metalloenzymes play a crucial role in physiological processes including antioxidant, anti-inflammatory, and immune responses, as well as apoptosis. Aberrant enzyme activity can lead to various human diseases. In this review, we summarize zinc homeostasis, the roles of zinc in zinc metalloenzymes, the physiological processes of zinc metalloenzymes, and aberrant zinc metalloenzymes in human diseases. In addition, potential mechanisms of action are also discussed. This comprehensive understanding of the mechanisms of action of the regulatory functions of zinc in enzyme activity could inform novel zinc-micronutrient-supply strategies for the treatment of diseases.https://www.mdpi.com/2072-6643/13/12/4456zinczinc metalloenzymeenzyme activityhuman disease |
| spellingShingle | Yunqi Cheng Hongping Chen Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms Nutrients zinc zinc metalloenzyme enzyme activity human disease |
| title | Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms |
| title_full | Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms |
| title_fullStr | Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms |
| title_full_unstemmed | Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms |
| title_short | Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms |
| title_sort | aberrance of zinc metalloenzymes induced human diseases and its potential mechanisms |
| topic | zinc zinc metalloenzyme enzyme activity human disease |
| url | https://www.mdpi.com/2072-6643/13/12/4456 |
| work_keys_str_mv | AT yunqicheng aberranceofzincmetalloenzymesinducedhumandiseasesanditspotentialmechanisms AT hongpingchen aberranceofzincmetalloenzymesinducedhumandiseasesanditspotentialmechanisms |