Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions
Osteoarthritis (OA) is one of the most common chronic diseases in human and animal joints. The joints undergo several morphological and histological changes during the development of radiographically visible osteoarthritis. The most discussed changes include synovial inflammation, the massive destru...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13028 |
| _version_ | 1797582448842768384 |
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| author | Frederike Werry Emilia Mazur Lars F. H. Theyse Frank Edlich |
| author_facet | Frederike Werry Emilia Mazur Lars F. H. Theyse Frank Edlich |
| author_sort | Frederike Werry |
| collection | DOAJ |
| description | Osteoarthritis (OA) is one of the most common chronic diseases in human and animal joints. The joints undergo several morphological and histological changes during the development of radiographically visible osteoarthritis. The most discussed changes include synovial inflammation, the massive destruction of articular cartilage and ongoing joint destruction accompanied by massive joint pain in the later stadium. Either the increased apoptosis of chondrocytes or the insufficient apoptosis of inflammatory macrophages and synovial fibroblasts are likely to underly this process. In this review, we discuss the current state of research on the pathogenesis of OA with special regard to the involvement of apoptosis. |
| first_indexed | 2024-03-10T23:22:29Z |
| format | Article |
| id | doaj.art-4c106244bb8e435c96f327b1891f8672 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:22:29Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4c106244bb8e435c96f327b1891f86722023-11-19T08:11:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171302810.3390/ijms241713028Apoptosis Regulation in Osteoarthritis and the Influence of Lipid InteractionsFrederike Werry0Emilia Mazur1Lars F. H. Theyse2Frank Edlich3Institute of Biochemistry, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, GermanySoft Tissue & Orthopaedic Surgery Service, Department for Small Animals, College of Veterinary Medicine, University of Leipzig, 04103 Leipzig, GermanySoft Tissue & Orthopaedic Surgery Service, Department for Small Animals, College of Veterinary Medicine, University of Leipzig, 04103 Leipzig, GermanyInstitute of Biochemistry, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, GermanyOsteoarthritis (OA) is one of the most common chronic diseases in human and animal joints. The joints undergo several morphological and histological changes during the development of radiographically visible osteoarthritis. The most discussed changes include synovial inflammation, the massive destruction of articular cartilage and ongoing joint destruction accompanied by massive joint pain in the later stadium. Either the increased apoptosis of chondrocytes or the insufficient apoptosis of inflammatory macrophages and synovial fibroblasts are likely to underly this process. In this review, we discuss the current state of research on the pathogenesis of OA with special regard to the involvement of apoptosis.https://www.mdpi.com/1422-0067/24/17/13028osteoarthritisapoptosislipid interactionsBCL-2 protein familychondrocyteautophagy |
| spellingShingle | Frederike Werry Emilia Mazur Lars F. H. Theyse Frank Edlich Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions International Journal of Molecular Sciences osteoarthritis apoptosis lipid interactions BCL-2 protein family chondrocyte autophagy |
| title | Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions |
| title_full | Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions |
| title_fullStr | Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions |
| title_full_unstemmed | Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions |
| title_short | Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions |
| title_sort | apoptosis regulation in osteoarthritis and the influence of lipid interactions |
| topic | osteoarthritis apoptosis lipid interactions BCL-2 protein family chondrocyte autophagy |
| url | https://www.mdpi.com/1422-0067/24/17/13028 |
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