The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal
The treatment of locally advanced rectal cancer (LARC) has evolved during the last decades, but recurrence remains a problem. Circulating tumor DNA (ctDNA) may result in an individualized treatment approach with improved survival and quality of life, but diverging results impede further development....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/9/2252 |
| _version_ | 1797505386836656128 |
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| author | Edina Dizdarevic Torben Frøstrup Hansen Anders Jakobsen |
| author_facet | Edina Dizdarevic Torben Frøstrup Hansen Anders Jakobsen |
| author_sort | Edina Dizdarevic |
| collection | DOAJ |
| description | The treatment of locally advanced rectal cancer (LARC) has evolved during the last decades, but recurrence remains a problem. Circulating tumor DNA (ctDNA) may result in an individualized treatment approach with improved survival and quality of life, but diverging results impede further development. In this systematic review, we addressed the quality of reporting and its impact on the interpretation of ctDNA results. We performed a systematic literature search using subject headings and search terms related to ctDNA and rectal cancer. The Quality of Prognostic Studies (QUIPS) tool was used to assess bias. Nine studies, with substantial heterogeneity, were included in the analysis. Three out of nine articles had moderate or high risk of bias. No association was found between treatment response and ctDNA status at baseline. There was a negative association between ctDNA positivity at baseline, before and after surgery and survival. The ctDNA status may be of importance to the long-term prognosis, but the area of research is new and is short of dedicated studies. There is an obvious need for standardization in ctDNA research, and the issue should be addressed in future research. |
| first_indexed | 2024-03-10T04:17:55Z |
| format | Article |
| id | doaj.art-4c1230adea9e4b04ae9634c6163f6bac |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:17:55Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4c1230adea9e4b04ae9634c6163f6bac2023-11-23T07:57:00ZengMDPI AGCancers2072-66942022-04-01149225210.3390/cancers14092252The Prognostic Importance of ctDNA in Rectal Cancer: A Critical ReappraisalEdina Dizdarevic0Torben Frøstrup Hansen1Anders Jakobsen2Danish Colorectal Cancer Center South, Department of Oncology, University Hospital of Southern Denmark, 7100 Vejle, DenmarkDanish Colorectal Cancer Center South, Department of Oncology, University Hospital of Southern Denmark, 7100 Vejle, DenmarkDanish Colorectal Cancer Center South, Department of Oncology, University Hospital of Southern Denmark, 7100 Vejle, DenmarkThe treatment of locally advanced rectal cancer (LARC) has evolved during the last decades, but recurrence remains a problem. Circulating tumor DNA (ctDNA) may result in an individualized treatment approach with improved survival and quality of life, but diverging results impede further development. In this systematic review, we addressed the quality of reporting and its impact on the interpretation of ctDNA results. We performed a systematic literature search using subject headings and search terms related to ctDNA and rectal cancer. The Quality of Prognostic Studies (QUIPS) tool was used to assess bias. Nine studies, with substantial heterogeneity, were included in the analysis. Three out of nine articles had moderate or high risk of bias. No association was found between treatment response and ctDNA status at baseline. There was a negative association between ctDNA positivity at baseline, before and after surgery and survival. The ctDNA status may be of importance to the long-term prognosis, but the area of research is new and is short of dedicated studies. There is an obvious need for standardization in ctDNA research, and the issue should be addressed in future research.https://www.mdpi.com/2072-6694/14/9/2252rectal cancercolorectal cancerctDNAliquid biopsybiomarkersQUIPS |
| spellingShingle | Edina Dizdarevic Torben Frøstrup Hansen Anders Jakobsen The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal Cancers rectal cancer colorectal cancer ctDNA liquid biopsy biomarkers QUIPS |
| title | The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal |
| title_full | The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal |
| title_fullStr | The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal |
| title_full_unstemmed | The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal |
| title_short | The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal |
| title_sort | prognostic importance of ctdna in rectal cancer a critical reappraisal |
| topic | rectal cancer colorectal cancer ctDNA liquid biopsy biomarkers QUIPS |
| url | https://www.mdpi.com/2072-6694/14/9/2252 |
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