Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors
Immune checkpoint inhibitors have revolutionized the treatment paradigm of several cancers. However, not all patients respond to treatment. Tumor cells reprogram metabolic pathways to facilitate growth and proliferation. This shift in metabolic pathways creates fierce competition with immune cells f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Innovative Healthcare Institute
2023-05-01
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| Series: | Journal of Immunotherapy and Precision Oncology |
| Subjects: | |
| Online Access: | https://jipo.org/doi/pdf/10.36401/JIPO-22-27 |
| _version_ | 1797776370732892160 |
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| author | Zainab Fatima Abdulrahman Abonofal Bettzy Stephen |
| author_facet | Zainab Fatima Abdulrahman Abonofal Bettzy Stephen |
| author_sort | Zainab Fatima |
| collection | DOAJ |
| description | Immune checkpoint inhibitors have revolutionized the treatment paradigm of several cancers. However, not all patients respond to treatment. Tumor cells reprogram metabolic pathways to facilitate growth and proliferation. This shift in metabolic pathways creates fierce competition with immune cells for nutrients in the tumor microenvironment and generates by-products harmful for immune cell differentiation and growth. In this review, we discuss these metabolic alterations and the current therapeutic strategies to mitigate these alterations to metabolic pathways that can be used in combination with checkpoint blockade to offer a new path forward in cancer management. |
| first_indexed | 2024-03-12T22:50:00Z |
| format | Article |
| id | doaj.art-4c14fec289804f55a76bcb6bc1c64cc5 |
| institution | Directory Open Access Journal |
| issn | 2666-2345 2590-017X |
| language | English |
| last_indexed | 2024-03-12T22:50:00Z |
| publishDate | 2023-05-01 |
| publisher | Innovative Healthcare Institute |
| record_format | Article |
| series | Journal of Immunotherapy and Precision Oncology |
| spelling | doaj.art-4c14fec289804f55a76bcb6bc1c64cc52023-07-20T14:50:11ZengInnovative Healthcare InstituteJournal of Immunotherapy and Precision Oncology2666-23452590-017X2023-05-01629110210.36401/JIPO-22-27i2590-017X-6-2-91Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint InhibitorsZainab Fatima0Abdulrahman Abonofal1Bettzy Stephen21 Department of Hospice and Palliative Care, Virginia Commonwealth University, Richmond, VA, USA2 Department of Medicine, Section of Hematology/Oncology, West Virginia University, Morgantown, WV, USA3 Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USAImmune checkpoint inhibitors have revolutionized the treatment paradigm of several cancers. However, not all patients respond to treatment. Tumor cells reprogram metabolic pathways to facilitate growth and proliferation. This shift in metabolic pathways creates fierce competition with immune cells for nutrients in the tumor microenvironment and generates by-products harmful for immune cell differentiation and growth. In this review, we discuss these metabolic alterations and the current therapeutic strategies to mitigate these alterations to metabolic pathways that can be used in combination with checkpoint blockade to offer a new path forward in cancer management.https://jipo.org/doi/pdf/10.36401/JIPO-22-27immune checkpoint inhibitorsglucose metabolismamino acid metabolismlipid metabolismadenosine pathway |
| spellingShingle | Zainab Fatima Abdulrahman Abonofal Bettzy Stephen Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors Journal of Immunotherapy and Precision Oncology immune checkpoint inhibitors glucose metabolism amino acid metabolism lipid metabolism adenosine pathway |
| title | Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors |
| title_full | Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors |
| title_fullStr | Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors |
| title_full_unstemmed | Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors |
| title_short | Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors |
| title_sort | targeting cancer metabolism to improve outcomes with immune checkpoint inhibitors |
| topic | immune checkpoint inhibitors glucose metabolism amino acid metabolism lipid metabolism adenosine pathway |
| url | https://jipo.org/doi/pdf/10.36401/JIPO-22-27 |
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