Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs
Abstract Background With the improvement of treatment and prognosis for patients with late malignant diseases, certain malignancies with distant metastasis (M1 category) have been further classified into M1a (single metastatic site) and M1b (multiple metastatic sites) category in the staging system....
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-020-01431-8 |
| _version_ | 1828854452247855104 |
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| author | Fang Feng Wei Cai Gaoming Wang Weigang Chen Haochang Yang Mingyu Sun Li Zhou |
| author_facet | Fang Feng Wei Cai Gaoming Wang Weigang Chen Haochang Yang Mingyu Sun Li Zhou |
| author_sort | Fang Feng |
| collection | DOAJ |
| description | Abstract Background With the improvement of treatment and prognosis for patients with late malignant diseases, certain malignancies with distant metastasis (M1 category) have been further classified into M1a (single metastatic site) and M1b (multiple metastatic sites) category in the staging system. We aimed to assess the feasibility of sub-classifying metastatic pancreatic adenocarcinoma (mPA) into M1a and M1b category depending on the number of metastatic organs. Methods Patient records were collected from the Surveillance, Epidemiology, and End Results (SEER) database (2010–2015). Univariable and multivariable analyses were performed using the Cox regression model. Then survival analysis was determined using the Kaplan–Meier method. Results A total of 11,885 patients were included in this analysis, including 9425 patients with single metastasis and 2460 patients with multiple metastases. Multivariable analysis showed that gender, age, marital status, grade, surgery, chemotherapy, and radiotherapy were independent prognostic factors for patients with single metastasis; gender, age, marital status, grade, chemotherapy and radiotherapy were independent prognostic factors for patients with multiple metastases. Notably, surgery was an independent prognostic factor for patients with single metastasis (P < 0.001) but not for patients with multiple metastases (P = 0.134). Kaplan–Meier analysis showed that patients with single metastasis (M1a) had better survival outcomes than patients with multiple metastases (M1b) (P < 0.001). Conclusions PA patients with M1 diseases could be divided into M1a (single metastasis) category and M1b (multiple metastases) category by the number of metastatic organs. The subclassification would facilitate individualized treatment for late PA patients. Surgery was associated with lower mortality in M1a patients but not significantly in M1b patients. |
| first_indexed | 2024-12-13T00:34:24Z |
| format | Article |
| id | doaj.art-4c185f7a81de4cd9abf515242fba504a |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-13T00:34:24Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-4c185f7a81de4cd9abf515242fba504a2022-12-22T00:05:15ZengBMCBMC Gastroenterology1471-230X2020-08-012011810.1186/s12876-020-01431-8Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organsFang Feng0Wei Cai1Gaoming Wang2Weigang Chen3Haochang Yang4Mingyu Sun5Li Zhou6Department of Oncology, Suzhou Ninth People’s HospitalDepartment of Thoracic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast UniversityDepartment of Thoracic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast UniversityDepartment of Thoracic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast UniversityCollege of Clinical Medicine, Binzhou Medical UniversityDepartment of Breast Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast UniversityDepartment of Oncology, Suzhou Ninth People’s HospitalAbstract Background With the improvement of treatment and prognosis for patients with late malignant diseases, certain malignancies with distant metastasis (M1 category) have been further classified into M1a (single metastatic site) and M1b (multiple metastatic sites) category in the staging system. We aimed to assess the feasibility of sub-classifying metastatic pancreatic adenocarcinoma (mPA) into M1a and M1b category depending on the number of metastatic organs. Methods Patient records were collected from the Surveillance, Epidemiology, and End Results (SEER) database (2010–2015). Univariable and multivariable analyses were performed using the Cox regression model. Then survival analysis was determined using the Kaplan–Meier method. Results A total of 11,885 patients were included in this analysis, including 9425 patients with single metastasis and 2460 patients with multiple metastases. Multivariable analysis showed that gender, age, marital status, grade, surgery, chemotherapy, and radiotherapy were independent prognostic factors for patients with single metastasis; gender, age, marital status, grade, chemotherapy and radiotherapy were independent prognostic factors for patients with multiple metastases. Notably, surgery was an independent prognostic factor for patients with single metastasis (P < 0.001) but not for patients with multiple metastases (P = 0.134). Kaplan–Meier analysis showed that patients with single metastasis (M1a) had better survival outcomes than patients with multiple metastases (M1b) (P < 0.001). Conclusions PA patients with M1 diseases could be divided into M1a (single metastasis) category and M1b (multiple metastases) category by the number of metastatic organs. The subclassification would facilitate individualized treatment for late PA patients. Surgery was associated with lower mortality in M1a patients but not significantly in M1b patients.http://link.springer.com/article/10.1186/s12876-020-01431-8Metastatic pancreatic adenocarcinomaSEEROverall survivalAJCC |
| spellingShingle | Fang Feng Wei Cai Gaoming Wang Weigang Chen Haochang Yang Mingyu Sun Li Zhou Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs BMC Gastroenterology Metastatic pancreatic adenocarcinoma SEER Overall survival AJCC |
| title | Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs |
| title_full | Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs |
| title_fullStr | Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs |
| title_full_unstemmed | Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs |
| title_short | Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs |
| title_sort | metastatic pancreatic adenocarcinomas could be classified into m1a and m1b category by the number of metastatic organs |
| topic | Metastatic pancreatic adenocarcinoma SEER Overall survival AJCC |
| url | http://link.springer.com/article/10.1186/s12876-020-01431-8 |
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