Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversia...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-08-01
|
| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/526312 |
| _version_ | 1818050157756809216 |
|---|---|
| author | Mayuko Amagai Sadanori Furudate Kentaro Ohuchi Toshiya Takahashi Emi Yamazaki Hiromu Chiba Yoshihide Asano Taku Fujimura |
| author_facet | Mayuko Amagai Sadanori Furudate Kentaro Ohuchi Toshiya Takahashi Emi Yamazaki Hiromu Chiba Yoshihide Asano Taku Fujimura |
| author_sort | Mayuko Amagai |
| collection | DOAJ |
| description | Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment. |
| first_indexed | 2024-12-10T10:49:01Z |
| format | Article |
| id | doaj.art-4c18d05cfbc04ba99174a9bbf344291b |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-10T10:49:01Z |
| publishDate | 2022-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-4c18d05cfbc04ba99174a9bbf344291b2022-12-22T01:52:05ZengKarger PublishersCase Reports in Oncology1662-65752022-08-0115272673110.1159/000526312526312Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin DiftitoxMayuko Amagaihttps://orcid.org/0000-0002-8243-8537Sadanori FurudateKentaro Ohuchihttps://orcid.org/0000-0002-6786-7704Toshiya Takahashihttps://orcid.org/0000-0001-9742-2282Emi YamazakiHiromu ChibaYoshihide AsanoTaku FujimuraPrimary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment.https://www.karger.com/Article/FullText/526312pcalcldenileukin diftitoxchemotherapytumor-infiltrating cellsgranulysin |
| spellingShingle | Mayuko Amagai Sadanori Furudate Kentaro Ohuchi Toshiya Takahashi Emi Yamazaki Hiromu Chiba Yoshihide Asano Taku Fujimura Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox Case Reports in Oncology pcalcl denileukin diftitox chemotherapy tumor-infiltrating cells granulysin |
| title | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
| title_full | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
| title_fullStr | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
| title_full_unstemmed | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
| title_short | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
| title_sort | successful treatment of primary cutaneous anaplastic large cell lymphoma with denileukin diftitox |
| topic | pcalcl denileukin diftitox chemotherapy tumor-infiltrating cells granulysin |
| url | https://www.karger.com/Article/FullText/526312 |
| work_keys_str_mv | AT mayukoamagai successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT sadanorifurudate successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT kentaroohuchi successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT toshiyatakahashi successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT emiyamazaki successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT hiromuchiba successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT yoshihideasano successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT takufujimura successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox |