Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved]
Background: Recent studies show that adults with intellectual disabilities (ID) have high incidence of major osteoporotic fracture, especially hip fracture. In those ≥ 50 years, women and men with ID have an approximately two and four times higher rate of hip fracture than women and men without ID. ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2022-12-01
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| Series: | NIHR Open Research |
| Subjects: | |
| Online Access: | https://openresearch.nihr.ac.uk/articles/2-61/v1 |
| _version_ | 1797662180627185664 |
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| author | Valeria Frighi Margaret Smith Tim A. Holt |
| author_facet | Valeria Frighi Margaret Smith Tim A. Holt |
| author_sort | Valeria Frighi |
| collection | DOAJ |
| description | Background: Recent studies show that adults with intellectual disabilities (ID) have high incidence of major osteoporotic fracture, especially hip fracture. In those ≥ 50 years, women and men with ID have an approximately two and four times higher rate of hip fracture than women and men without ID. Increased awareness of osteoporotic fracture risk in ID may lead to wider use of antiresorptiverugs (bisphosphonates and denosumab) in this population. We aimed to compare, between people with and without ID, the incidence of 1) major side effects, namely medication related osteoporosis of the jaw (ONJ) and oesophagitis; 2) oral pathology, which can be a risk factor for ONJ. Methods: Exploratory study investigating safety of first line osteoporosis medication within the population of a previous study comparing fracture incidence in people with and without ID in the GOLD database of the Clinical Practice Research Datalink 1998-2017. Results: The percentage of people on antiresorptive drugs was identical in the ID and non ID group (1.4%). The number of individuals who developed ONJ and oesophagitis during the study was too low to allow an accurate estimate of incidence of the events and a comparison between the two groups. The incidence of any oral pathology was 119.31 vs 64.68/10000 person year in the ID vs non ID group. Conclusions: Medication related ONJ and oesophagitis are rare in people with and without ID. There is no reason based on our findings to use antiresorptives differently in people with ID as in the rest of the population. However, the potential for side effects of antiresorptives will inherently increase with wider use of these drugs. Given the higher incidence of oral pathology in people with ID, which could put them at higher risk of ONJ, precautions should be taken to prevent this complication by attention to oral health. |
| first_indexed | 2024-03-11T18:56:19Z |
| format | Article |
| id | doaj.art-4c1946d52c5d431ea10441e7bf925e04 |
| institution | Directory Open Access Journal |
| issn | 2633-4402 |
| language | English |
| last_indexed | 2024-03-11T18:56:19Z |
| publishDate | 2022-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | NIHR Open Research |
| spelling | doaj.art-4c1946d52c5d431ea10441e7bf925e042023-10-11T00:00:00ZengF1000 Research LtdNIHR Open Research2633-44022022-12-01214480Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved]Valeria Frighi0https://orcid.org/0000-0001-8177-8778Margaret Smith1Tim A. Holt2Dept. of Psychiatry, University of Oxford, Oxford, OX3 7JX, UKNuffield Dept. of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UKDept. of Psychiatry, University of Oxford, Oxford, OX3 7JX, UKBackground: Recent studies show that adults with intellectual disabilities (ID) have high incidence of major osteoporotic fracture, especially hip fracture. In those ≥ 50 years, women and men with ID have an approximately two and four times higher rate of hip fracture than women and men without ID. Increased awareness of osteoporotic fracture risk in ID may lead to wider use of antiresorptiverugs (bisphosphonates and denosumab) in this population. We aimed to compare, between people with and without ID, the incidence of 1) major side effects, namely medication related osteoporosis of the jaw (ONJ) and oesophagitis; 2) oral pathology, which can be a risk factor for ONJ. Methods: Exploratory study investigating safety of first line osteoporosis medication within the population of a previous study comparing fracture incidence in people with and without ID in the GOLD database of the Clinical Practice Research Datalink 1998-2017. Results: The percentage of people on antiresorptive drugs was identical in the ID and non ID group (1.4%). The number of individuals who developed ONJ and oesophagitis during the study was too low to allow an accurate estimate of incidence of the events and a comparison between the two groups. The incidence of any oral pathology was 119.31 vs 64.68/10000 person year in the ID vs non ID group. Conclusions: Medication related ONJ and oesophagitis are rare in people with and without ID. There is no reason based on our findings to use antiresorptives differently in people with ID as in the rest of the population. However, the potential for side effects of antiresorptives will inherently increase with wider use of these drugs. Given the higher incidence of oral pathology in people with ID, which could put them at higher risk of ONJ, precautions should be taken to prevent this complication by attention to oral health.https://openresearch.nihr.ac.uk/articles/2-61/v1Intellectual disabilities; osteoporosis; antiresorptives; bisphosphonates; denosumab; osteonecrosis of the jaw; oesophagitiseng |
| spellingShingle | Valeria Frighi Margaret Smith Tim A. Holt Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved] NIHR Open Research Intellectual disabilities; osteoporosis; antiresorptives; bisphosphonates; denosumab; osteonecrosis of the jaw; oesophagitis eng |
| title | Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved] |
| title_full | Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved] |
| title_fullStr | Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved] |
| title_full_unstemmed | Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved] |
| title_short | Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: 2 approved] |
| title_sort | use and risk of side effects of antiresorptive medication in people with intellectual disabilities version 1 peer review 2 approved |
| topic | Intellectual disabilities; osteoporosis; antiresorptives; bisphosphonates; denosumab; osteonecrosis of the jaw; oesophagitis eng |
| url | https://openresearch.nihr.ac.uk/articles/2-61/v1 |
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