PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination

PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination

Summary: The function of poly(ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an intrinsic driver for oligodendroglial development and myelination. Genetic PARP1 depletion impairs the differentiat...

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Bibliographic Details
Main Authors: Yan Wang, Yanhong Zhang, Sheng Zhang, Bokyung Kim, Vanessa L. Hull, Jie Xu, Preeti Prabhu, Maria Gregory, Veronica Martinez-Cerdeno, Xinhua Zhan, Wenbin Deng, Fuzheng Guo
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
PARP1
PARylation
PARG
oligodendrocytes (OLs)
oligodendrocyte progenitor cells (OPCs)
myelination
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011426

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