Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning

Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning

Abstract Aging is associated with loss of circadian immune responses and circadian gene transcription in peripheral macrophages. Microglia, the resident macrophages of the brain, also show diurnal rhythmicity in regulating local immune responses and synaptic remodeling. To investigate the interactio...

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Bibliographic Details
Main Authors: Chinyere Agbaegbu Iweka, Erica Seigneur, Amira Latif Hernandez, Sur Herrera Paredes, Mica Cabrera, Eran Blacher, Connie Tsai Pasternak, Frank M. Longo, Luis de Lecea, Katrin I. Andreasson
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Neuroinflammation
Subjects:
Circadian clock
BMAL1
Microglia
Synaptic plasticity
Sleep–wake cycle
Online Access:https://doi.org/10.1186/s12974-023-02727-8

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