Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia

Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia

Mutations in the peroxisomal half-transporter ABCD1 cause X-linked adrenoleukodystrophy, resulting in elevated very long-chain fatty acids (VLCFA), progressive neurodegeneration and an associated pain syndrome that is poorly understood. In the nervous system of mice, we found ABCD1 expression to be...

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Bibliographic Details
Main Authors: Yi Gong, Fiza Laheji, Anna Berenson, April Qian, Sang-O Park, Rene Kok, Martin Selig, Ryan Hahn, Reza Sadjadi, Stephan Kemp, Florian Eichler
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
dorsal root ganglion (DRG)
X-linked adrenoleukodystrophy (X-ALD)
adrenomyeloneuropathy (AMN)
mechanical hypersensitivity
pain
PIEZO2
Online Access:https://www.mdpi.com/2073-4409/11/11/1842

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