| Summary: | Introduction: The severe acute respiratory syndrome (SARS)-CoV2 is a viral respiratory disease threatening worldwide public health, social stability, and financial development. Pathological hallmark for SARS-CoV-2 is an ineffective innate immune reaction. i.e., immune cells recognize it as dangerous toxins in place of self-antigen. Published data on neutralizing antibodies suggests their role in the prevention and treatment of infection SARS-CoV-2 through passive immunity in COVID-19. Objective: The present paper discusses the role of vishghna dravya in either flushing out or neutralization of toxins from the body. Material & Method: We developed the screening system based on Ayurveda & Modern pharmacology from different databases. Reported plants and minerals were retrieved from ancient texts. Furthermore, pharmacology method was used to preliminarily uncover the molecule mechanism. Results: Nine herbs and five metallic bhasmas having Vishaghna property were systematically reviewed, out of which four herbs and five metallic bhasmas have been reported to possess neutralizing antibody potential. Vishagna dravya works on concept of Samana pratyarbdha, the inherent qualities of the predominant mahabhutas. Madhura rasa (six), Katu Rasa (Five), Tikta Rasa (seven), Kasaya Rasa (two) have Prithvi, Vayu, Akash & Agni Mahabhuta that may exert neutralizing effect by making the cells more strong, inhibits the absorption of virus & increasing the various metabolic activities. Conclusion: To meet this challenge, this article discusses some published Ayurveda herbs and Nano metals which may neutralize the virus toxin for the prevention and treatment of infection by SARS-CoV-2.
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