A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique
The solid dispersion method was originally used to improve the dissolution properties and the bioavailability of poorly water soluble drugs by dispersing them into water soluble carriers. In addition to the above, dissolution retardation through solid dispersion technique using water insoluble and w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Pharmacy, Cairo University
2012-12-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093112000294 |
| _version_ | 1797970093644185600 |
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| author | Tapan Kumar Giri Kulesh Kumar Amit Alexander Ajazuddin Hemant Badwaik Dulal Krishna Tripathi |
| author_facet | Tapan Kumar Giri Kulesh Kumar Amit Alexander Ajazuddin Hemant Badwaik Dulal Krishna Tripathi |
| author_sort | Tapan Kumar Giri |
| collection | DOAJ |
| description | The solid dispersion method was originally used to improve the dissolution properties and the bioavailability of poorly water soluble drugs by dispersing them into water soluble carriers. In addition to the above, dissolution retardation through solid dispersion technique using water insoluble and water swellable polymer for the development of controlled release dosage forms has become a field of interest in recent years. Development of controlled release solid dispersion has a great advantage for bypassing the risk of a burst release of drug; since the structure of the solid dispersion is monolithic where drug molecules homogeneously disperse. Despite the remarkable potential and extensive research being conducted on controlled release solid dispersion system, commercialization and large scale production are limited. The author expects that recent technological advances may overcome the existing limitations and facilitate the commercial utilization of the techniques for manufacture of controlled release solid dispersions. This article begins with an overview of the different carriers being used for the preparation of controlled release solid dispersion and also different techniques being used for the purpose. Kinetics of drug release from these controlled release solid dispersions and the relevant mathematical modeling have also been reviewed in this manuscript. |
| first_indexed | 2024-04-11T03:12:35Z |
| format | Article |
| id | doaj.art-4c21f8043e8645718f054653f6bc1f04 |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T03:12:35Z |
| publishDate | 2012-12-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-4c21f8043e8645718f054653f6bc1f042023-01-02T11:18:20ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312012-12-0150214715910.1016/j.bfopcu.2012.07.002A novel and alternative approach to controlled release drug delivery system based on solid dispersion techniqueTapan Kumar GiriKulesh KumarAmit AlexanderAjazuddinHemant BadwaikDulal Krishna TripathiThe solid dispersion method was originally used to improve the dissolution properties and the bioavailability of poorly water soluble drugs by dispersing them into water soluble carriers. In addition to the above, dissolution retardation through solid dispersion technique using water insoluble and water swellable polymer for the development of controlled release dosage forms has become a field of interest in recent years. Development of controlled release solid dispersion has a great advantage for bypassing the risk of a burst release of drug; since the structure of the solid dispersion is monolithic where drug molecules homogeneously disperse. Despite the remarkable potential and extensive research being conducted on controlled release solid dispersion system, commercialization and large scale production are limited. The author expects that recent technological advances may overcome the existing limitations and facilitate the commercial utilization of the techniques for manufacture of controlled release solid dispersions. This article begins with an overview of the different carriers being used for the preparation of controlled release solid dispersion and also different techniques being used for the purpose. Kinetics of drug release from these controlled release solid dispersions and the relevant mathematical modeling have also been reviewed in this manuscript.http://www.sciencedirect.com/science/article/pii/S1110093112000294Controlled releaseFreeze dryingHot stage extrusionRelease mechanismSolid dispersion |
| spellingShingle | Tapan Kumar Giri Kulesh Kumar Amit Alexander Ajazuddin Hemant Badwaik Dulal Krishna Tripathi A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique Bulletin of Faculty of Pharmacy Cairo University Controlled release Freeze drying Hot stage extrusion Release mechanism Solid dispersion |
| title | A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique |
| title_full | A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique |
| title_fullStr | A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique |
| title_full_unstemmed | A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique |
| title_short | A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique |
| title_sort | novel and alternative approach to controlled release drug delivery system based on solid dispersion technique |
| topic | Controlled release Freeze drying Hot stage extrusion Release mechanism Solid dispersion |
| url | http://www.sciencedirect.com/science/article/pii/S1110093112000294 |
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