A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study
Background: Ischemic heart disease (IHD) is a major cause of death globally. Countries vary in their rates, and changes have occurred over time. Nowadays, developing countries pose new public health challenges. Objectives: The objective of the present study was to appraise the alterations in the lev...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402032154X |
| _version_ | 1818302562759081984 |
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| author | Shamima Nasrin Anonna Sayed Koushik Ahamed Md. Giash Uddin Md. Tarek Adnan S.M. Naim Uddin Md. Saddam Hussain Md. Shalahuddin Millat Latifa Bulbul Rita Bhatta Md. Shahid Sarwar Md. Mamun ur Rashid Jakir Ahmed Chowdhury Mohammad Safiqul Islam |
| author_facet | Shamima Nasrin Anonna Sayed Koushik Ahamed Md. Giash Uddin Md. Tarek Adnan S.M. Naim Uddin Md. Saddam Hussain Md. Shalahuddin Millat Latifa Bulbul Rita Bhatta Md. Shahid Sarwar Md. Mamun ur Rashid Jakir Ahmed Chowdhury Mohammad Safiqul Islam |
| author_sort | Shamima Nasrin Anonna |
| collection | DOAJ |
| description | Background: Ischemic heart disease (IHD) is a major cause of death globally. Countries vary in their rates, and changes have occurred over time. Nowadays, developing countries pose new public health challenges. Objectives: The objective of the present study was to appraise the alterations in the levels of serum Zn, Cu, Fe, and Mn that occur in patients with ischemic heart disease and to depict the correlations of the effects of these changes that lead to the pathogenesis of IHD. Methods: Zn, Cu, Fe, and Mn in the IHD patients were determined by Atomic Absorption Spectroscopy (AAS). Results: This study evaluated 52 patients with IHD, and 61 healthy volunteers served as controls. The primary outcomes of interest were explored regarding the correlations of the serum levels of these trace elements in patients with IHD. The secondary outcomes were explored in terms of inter-element relations to connect them with the pathogenesis of IHD. Our study found significantly reduced levels of Zn and Cu (2.50 ± 0.19 mg/L and 2.52 ± 0.17 mg/L, respectively) and an elevated level of Fe (148.97 ± 17.25 mg/L) in the patient group with IHD. The level of Mn (7.32 ± 1.23 mg/L) was elevated in the sera of the patients with ischemic heart disease (IHD) compared to healthy control subjects. Conclusion: Our results indicate strong associations of the pathogenesis of IHD with depleted serum levels of Zn and Cu and elevated Fe and Mn levels, which may provide a prognostic tool for the treatment of this concerning the disease. |
| first_indexed | 2024-12-13T05:40:53Z |
| format | Article |
| id | doaj.art-4c22e025ac3242debff7b2976efbb41c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-13T05:40:53Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4c22e025ac3242debff7b2976efbb41c2022-12-21T23:57:47ZengElsevierHeliyon2405-84402020-10-01610e05311A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control studyShamima Nasrin Anonna0Sayed Koushik Ahamed1Md. Giash Uddin2Md. Tarek Adnan3S.M. Naim Uddin4Md. Saddam Hussain5Md. Shalahuddin Millat6Latifa Bulbul7Rita Bhatta8Md. Shahid Sarwar9Md. Mamun ur Rashid10Jakir Ahmed Chowdhury11Mohammad Safiqul Islam12Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmacy, Comilla University, Comilla 3506, BangladeshDepartment of Pharmacy, University of Chittagong, Chittagong 4331, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmacy, University of Chittagong, Chittagong 4331, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshDepartment of Pharmaceutical Technology, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh; Corresponding author.Background: Ischemic heart disease (IHD) is a major cause of death globally. Countries vary in their rates, and changes have occurred over time. Nowadays, developing countries pose new public health challenges. Objectives: The objective of the present study was to appraise the alterations in the levels of serum Zn, Cu, Fe, and Mn that occur in patients with ischemic heart disease and to depict the correlations of the effects of these changes that lead to the pathogenesis of IHD. Methods: Zn, Cu, Fe, and Mn in the IHD patients were determined by Atomic Absorption Spectroscopy (AAS). Results: This study evaluated 52 patients with IHD, and 61 healthy volunteers served as controls. The primary outcomes of interest were explored regarding the correlations of the serum levels of these trace elements in patients with IHD. The secondary outcomes were explored in terms of inter-element relations to connect them with the pathogenesis of IHD. Our study found significantly reduced levels of Zn and Cu (2.50 ± 0.19 mg/L and 2.52 ± 0.17 mg/L, respectively) and an elevated level of Fe (148.97 ± 17.25 mg/L) in the patient group with IHD. The level of Mn (7.32 ± 1.23 mg/L) was elevated in the sera of the patients with ischemic heart disease (IHD) compared to healthy control subjects. Conclusion: Our results indicate strong associations of the pathogenesis of IHD with depleted serum levels of Zn and Cu and elevated Fe and Mn levels, which may provide a prognostic tool for the treatment of this concerning the disease.http://www.sciencedirect.com/science/article/pii/S240584402032154XCardiologyBiochemistryMolecular biologyPathophysiologyPublic healthPharmacology |
| spellingShingle | Shamima Nasrin Anonna Sayed Koushik Ahamed Md. Giash Uddin Md. Tarek Adnan S.M. Naim Uddin Md. Saddam Hussain Md. Shalahuddin Millat Latifa Bulbul Rita Bhatta Md. Shahid Sarwar Md. Mamun ur Rashid Jakir Ahmed Chowdhury Mohammad Safiqul Islam A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study Heliyon Cardiology Biochemistry Molecular biology Pathophysiology Public health Pharmacology |
| title | A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study |
| title_full | A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study |
| title_fullStr | A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study |
| title_full_unstemmed | A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study |
| title_short | A clinical evaluation of the alterations in the level of serum zinc, copper, iron, and manganese in the ischemic heart disease patients of Bangladesh - A case-control study |
| title_sort | clinical evaluation of the alterations in the level of serum zinc copper iron and manganese in the ischemic heart disease patients of bangladesh a case control study |
| topic | Cardiology Biochemistry Molecular biology Pathophysiology Public health Pharmacology |
| url | http://www.sciencedirect.com/science/article/pii/S240584402032154X |
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