The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis
Background: Neonatal necrotizing enterocolitis (NEC) is a complex and lethal inflammatory bowel necrosis that primarily affects premature infants. Gut dysbiosis has been implicated in the pathogenesis of NEC. We aim to assess the association between NEC and two other diseases in children, including...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00120/full |
| _version_ | 1818039353504432128 |
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| author | Shan-Ming Chen Shan-Ming Chen Jing-Yang Huang Jing-Yang Huang Ming-Chi Wu Ming-Chi Wu Ming-Chi Wu Jia-Yuh Chen Jia-Yuh Chen |
| author_facet | Shan-Ming Chen Shan-Ming Chen Jing-Yang Huang Jing-Yang Huang Ming-Chi Wu Ming-Chi Wu Ming-Chi Wu Jia-Yuh Chen Jia-Yuh Chen |
| author_sort | Shan-Ming Chen |
| collection | DOAJ |
| description | Background: Neonatal necrotizing enterocolitis (NEC) is a complex and lethal inflammatory bowel necrosis that primarily affects premature infants. Gut dysbiosis has been implicated in the pathogenesis of NEC. We aim to assess the association between NEC and two other diseases in children, including allergic diseases and constipation, considered to be associated with the alterations in gut microbiota composition.Methods: This retrospective population-based cohort study was conducted using the Taiwan Birth Registration Database, Birth Certificate Application, and National Health Insurance Research Database to inter-link the medical claims of neonates and their mothers. A total of 2,650,634 delivery events were retrieved from 2005 to 2015. We identified a NEC cohort and selected a comparison cohort according to propensity score matching (1:1). Cox proportional hazard regression models were used to determine possible associations of predictors and to obtain adjusted hazard ratios (aHRs).Results: A total of 1,145 subjects in the NEC cohort and 1,145 subjects in the matched cohort were analyzed during the observation period. No significant difference was observed in the incidence of allergic diseases between the two groups. NEC patients had a significant 30.7% increased risk of developing constipation (aHR = 1.307; 95% CI 1.089–1.568). The cumulative incidence of constipation was significantly higher in the NEC cohort than in the matched cohort by the end of follow-up (log-rank test P = 0.003).Conclusion: Infants with NEC have a significantly higher incidence rate of developing constipation and FTT but no increased risk of allergic diseases. |
| first_indexed | 2024-12-10T07:57:17Z |
| format | Article |
| id | doaj.art-4c23fbcb8a8948f88b43e39444c5622b |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-10T07:57:17Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-4c23fbcb8a8948f88b43e39444c5622b2022-12-22T01:56:52ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-04-01810.3389/fped.2020.00120499616The Risk of Developing Constipation After Neonatal Necrotizing EnterocolitisShan-Ming Chen0Shan-Ming Chen1Jing-Yang Huang2Jing-Yang Huang3Ming-Chi Wu4Ming-Chi Wu5Ming-Chi Wu6Jia-Yuh Chen7Jia-Yuh Chen8Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Pediatrics, School of Medicine, Chung Shan Medical University, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Medical Imaging, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Medical Informatics, Chung Shan Medical University, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Pediatrics, School of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, TaiwanBackground: Neonatal necrotizing enterocolitis (NEC) is a complex and lethal inflammatory bowel necrosis that primarily affects premature infants. Gut dysbiosis has been implicated in the pathogenesis of NEC. We aim to assess the association between NEC and two other diseases in children, including allergic diseases and constipation, considered to be associated with the alterations in gut microbiota composition.Methods: This retrospective population-based cohort study was conducted using the Taiwan Birth Registration Database, Birth Certificate Application, and National Health Insurance Research Database to inter-link the medical claims of neonates and their mothers. A total of 2,650,634 delivery events were retrieved from 2005 to 2015. We identified a NEC cohort and selected a comparison cohort according to propensity score matching (1:1). Cox proportional hazard regression models were used to determine possible associations of predictors and to obtain adjusted hazard ratios (aHRs).Results: A total of 1,145 subjects in the NEC cohort and 1,145 subjects in the matched cohort were analyzed during the observation period. No significant difference was observed in the incidence of allergic diseases between the two groups. NEC patients had a significant 30.7% increased risk of developing constipation (aHR = 1.307; 95% CI 1.089–1.568). The cumulative incidence of constipation was significantly higher in the NEC cohort than in the matched cohort by the end of follow-up (log-rank test P = 0.003).Conclusion: Infants with NEC have a significantly higher incidence rate of developing constipation and FTT but no increased risk of allergic diseases.https://www.frontiersin.org/article/10.3389/fped.2020.00120/fulladjusted hazard ratiosconstipationdysbiosisfailure to thrivenecrotizing enterocolitis |
| spellingShingle | Shan-Ming Chen Shan-Ming Chen Jing-Yang Huang Jing-Yang Huang Ming-Chi Wu Ming-Chi Wu Ming-Chi Wu Jia-Yuh Chen Jia-Yuh Chen The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis Frontiers in Pediatrics adjusted hazard ratios constipation dysbiosis failure to thrive necrotizing enterocolitis |
| title | The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis |
| title_full | The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis |
| title_fullStr | The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis |
| title_full_unstemmed | The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis |
| title_short | The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis |
| title_sort | risk of developing constipation after neonatal necrotizing enterocolitis |
| topic | adjusted hazard ratios constipation dysbiosis failure to thrive necrotizing enterocolitis |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00120/full |
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