A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases. Many studies have demonstrated that the release of NLRP3 inflammasome-mediated proinflammatory cytokines by the excessive activation of microglia is associated with the pathogenesis of AD and PD and...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/3/1324 |
| _version_ | 1797406160967434240 |
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| author | Jun Ho Lee Hong Jun Kim Jong Uk Kim Tae Han Yook Kyeong Han Kim Joo Young Lee Gabsik Yang |
| author_facet | Jun Ho Lee Hong Jun Kim Jong Uk Kim Tae Han Yook Kyeong Han Kim Joo Young Lee Gabsik Yang |
| author_sort | Jun Ho Lee |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases. Many studies have demonstrated that the release of NLRP3 inflammasome-mediated proinflammatory cytokines by the excessive activation of microglia is associated with the pathogenesis of AD and PD and suggested that the NLRP3 inflammasome plays an important role in AD and PD development. In both diseases, various stimuli, such as Aβ and α-synuclein, accelerate the formation of the NLRP3 inflammasome in microglia and induce pyroptosis through the expression of interleukin (IL)-1β, caspase-1, etc., where neuroinflammation contributes to gradual progression and deterioration. However, despite intensive research, the exact function and regulation of the NLRP3 inflammasome has not yet been clearly identified. Moreover, there have not yet been any experiments of clinical use, although many studies have recently been conducted to improve treatment of inflammatory diseases using various inhibitors for NLRP3 inflammasome pathways. However, recent studies have reported that various natural products show improvement effects in the in vivo models of AD and PD through the regulation of NLRP3 inflammasome assembly. Therefore, the present review provides an overview of natural extraction studies aimed at the prevention or treatment of NLRP3 inflammasome-mediated neurological disorders. It is suggested that the discovery and development of these various natural products could be a potential strategy for NLRP3 inflammasome-mediated AD and PD treatment. |
| first_indexed | 2024-03-09T03:21:20Z |
| format | Article |
| id | doaj.art-4c2410e39def4baba78111ce0185fc57 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:21:20Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4c2410e39def4baba78111ce0185fc572023-12-03T15:08:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01223132410.3390/ijms22031324A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s DiseaseJun Ho Lee0Hong Jun Kim1Jong Uk Kim2Tae Han Yook3Kyeong Han Kim4Joo Young Lee5Gabsik Yang6College of Korea Medicine, Woosuk University, Jeonju-si, Jeollabuk-do 54986, KoreaCollege of Korea Medicine, Woosuk University, Jeonju-si, Jeollabuk-do 54986, KoreaCollege of Korea Medicine, Woosuk University, Jeonju-si, Jeollabuk-do 54986, KoreaCollege of Korea Medicine, Woosuk University, Jeonju-si, Jeollabuk-do 54986, KoreaCollege of Korea Medicine, Woosuk University, Jeonju-si, Jeollabuk-do 54986, KoreaBK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, KoreaCollege of Korea Medicine, Woosuk University, Jeonju-si, Jeollabuk-do 54986, KoreaAlzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases. Many studies have demonstrated that the release of NLRP3 inflammasome-mediated proinflammatory cytokines by the excessive activation of microglia is associated with the pathogenesis of AD and PD and suggested that the NLRP3 inflammasome plays an important role in AD and PD development. In both diseases, various stimuli, such as Aβ and α-synuclein, accelerate the formation of the NLRP3 inflammasome in microglia and induce pyroptosis through the expression of interleukin (IL)-1β, caspase-1, etc., where neuroinflammation contributes to gradual progression and deterioration. However, despite intensive research, the exact function and regulation of the NLRP3 inflammasome has not yet been clearly identified. Moreover, there have not yet been any experiments of clinical use, although many studies have recently been conducted to improve treatment of inflammatory diseases using various inhibitors for NLRP3 inflammasome pathways. However, recent studies have reported that various natural products show improvement effects in the in vivo models of AD and PD through the regulation of NLRP3 inflammasome assembly. Therefore, the present review provides an overview of natural extraction studies aimed at the prevention or treatment of NLRP3 inflammasome-mediated neurological disorders. It is suggested that the discovery and development of these various natural products could be a potential strategy for NLRP3 inflammasome-mediated AD and PD treatment.https://www.mdpi.com/1422-0067/22/3/1324NLRP3 inflammasomeAlzheimer’s diseaseParkinson’s diseasenatural products |
| spellingShingle | Jun Ho Lee Hong Jun Kim Jong Uk Kim Tae Han Yook Kyeong Han Kim Joo Young Lee Gabsik Yang A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease International Journal of Molecular Sciences NLRP3 inflammasome Alzheimer’s disease Parkinson’s disease natural products |
| title | A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease |
| title_full | A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease |
| title_fullStr | A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease |
| title_full_unstemmed | A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease |
| title_short | A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease |
| title_sort | novel treatment strategy by natural products in nlrp3 inflammasome mediated neuroinflammation in alzheimer s and parkinson s disease |
| topic | NLRP3 inflammasome Alzheimer’s disease Parkinson’s disease natural products |
| url | https://www.mdpi.com/1422-0067/22/3/1324 |
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