Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis
Background and AimsThe impacts of Helicobacter pylori (H. pylori) eradication on the gastrointestinal microbiota are controversial, and whether the short-term and long-term changes in the gastrointestinal microbiota following different eradication regimens are consistent remains inconclusive. This s...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.913384/full |
| _version_ | 1817969490431836160 |
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| author | Bing Chen Bing Chen Xin-meng Li Xin-meng Li Ting Cai Ting Cai Fen Wang Fen Wang |
| author_facet | Bing Chen Bing Chen Xin-meng Li Xin-meng Li Ting Cai Ting Cai Fen Wang Fen Wang |
| author_sort | Bing Chen |
| collection | DOAJ |
| description | Background and AimsThe impacts of Helicobacter pylori (H. pylori) eradication on the gastrointestinal microbiota are controversial, and whether the short-term and long-term changes in the gastrointestinal microbiota following different eradication regimens are consistent remains inconclusive. This study aimed to examine the effects of various eradication regimens on the gastrointestinal microflora at follow-up evaluations within 7 days, at 1–3 months, and over 6 months changes in the gastrointestinal microbiota.Materials and MethodsStudies reported on the PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrails.gov databases before March 2022 were collected. Data analysis and visualization were conducted using Review Manager 5.4.1. The tool of the Cochrane Collaboration to assess the risk of bias was suitable for randomized controlled trials with the Newcastle–Ottawa scale for nonrandomized controlled trials. In addition, the process was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsAfter a series of rigorous screenings, a total of 34 articles with 1,204 participants were included for this review analysis. The results showed changes in the gut microflora at the phylum level or the family and genus levels. After metronidazole-containing triple therapy, the number of Enterobacteriaceae increased at 1–3 months follow-up. After Metronidazole-free triple therapy, Actinobacteria decreased significantly, and this trend lasted for more than 6 months. Within 7 days after eradication treatment, the follow-up results showed a decrease in the number of Lactobacillus. After Bismuth-containing quadruple therapy, the changes in Actinobacteria fluctuated with the follow-up time. The changes in Proteobacteria showed a downward trend lasting for 1–3 months after eradication but returned to baseline levels over 6 months after eradication. Subgroup analyses indicated that host age could influence changes in the gut microbiota.ConclusionDifferent eradication regimens had varied effects on the short-term and long-term abundance of the gastrointestinal microbiota, but the decreasing trend of the microbiota diversity was the same for all regimens at the short-term follow-up. This study summarizes the changes of gut microbiota at different stages after different eradication regimens and hope to provide some references for supplementing probiotics, while further studies is needed to support these findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021292726 |
| first_indexed | 2024-04-13T20:21:43Z |
| format | Article |
| id | doaj.art-4c246f3d5c15402fb2b8cdf7c53cd45f |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T20:21:43Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-4c246f3d5c15402fb2b8cdf7c53cd45f2022-12-22T02:31:31ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-07-011210.3389/fcimb.2022.913384913384Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysisBing Chen0Bing Chen1Xin-meng Li2Xin-meng Li3Ting Cai4Ting Cai5Fen Wang6Fen Wang7Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Non-resolving Inflammation and Cancer, Central South University, Changsha, ChinaDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Non-resolving Inflammation and Cancer, Central South University, Changsha, ChinaDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Non-resolving Inflammation and Cancer, Central South University, Changsha, ChinaDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Non-resolving Inflammation and Cancer, Central South University, Changsha, ChinaBackground and AimsThe impacts of Helicobacter pylori (H. pylori) eradication on the gastrointestinal microbiota are controversial, and whether the short-term and long-term changes in the gastrointestinal microbiota following different eradication regimens are consistent remains inconclusive. This study aimed to examine the effects of various eradication regimens on the gastrointestinal microflora at follow-up evaluations within 7 days, at 1–3 months, and over 6 months changes in the gastrointestinal microbiota.Materials and MethodsStudies reported on the PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrails.gov databases before March 2022 were collected. Data analysis and visualization were conducted using Review Manager 5.4.1. The tool of the Cochrane Collaboration to assess the risk of bias was suitable for randomized controlled trials with the Newcastle–Ottawa scale for nonrandomized controlled trials. In addition, the process was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsAfter a series of rigorous screenings, a total of 34 articles with 1,204 participants were included for this review analysis. The results showed changes in the gut microflora at the phylum level or the family and genus levels. After metronidazole-containing triple therapy, the number of Enterobacteriaceae increased at 1–3 months follow-up. After Metronidazole-free triple therapy, Actinobacteria decreased significantly, and this trend lasted for more than 6 months. Within 7 days after eradication treatment, the follow-up results showed a decrease in the number of Lactobacillus. After Bismuth-containing quadruple therapy, the changes in Actinobacteria fluctuated with the follow-up time. The changes in Proteobacteria showed a downward trend lasting for 1–3 months after eradication but returned to baseline levels over 6 months after eradication. Subgroup analyses indicated that host age could influence changes in the gut microbiota.ConclusionDifferent eradication regimens had varied effects on the short-term and long-term abundance of the gastrointestinal microbiota, but the decreasing trend of the microbiota diversity was the same for all regimens at the short-term follow-up. This study summarizes the changes of gut microbiota at different stages after different eradication regimens and hope to provide some references for supplementing probiotics, while further studies is needed to support these findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021292726https://www.frontiersin.org/articles/10.3389/fcimb.2022.913384/fullHelicobacter pylorigastrointestinal microbiotaeradication regimendysbiosismeta-analysis |
| spellingShingle | Bing Chen Bing Chen Xin-meng Li Xin-meng Li Ting Cai Ting Cai Fen Wang Fen Wang Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis Frontiers in Cellular and Infection Microbiology Helicobacter pylori gastrointestinal microbiota eradication regimen dysbiosis meta-analysis |
| title | Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis |
| title_full | Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis |
| title_fullStr | Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis |
| title_full_unstemmed | Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis |
| title_short | Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis |
| title_sort | short term and long term alterations of gastrointestinal microbiota with different h pylori eradication regimens a meta analysis |
| topic | Helicobacter pylori gastrointestinal microbiota eradication regimen dysbiosis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.913384/full |
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